9L04
Crystal structure of human ALK2 kinase domain with R206H mutation in complex with RK783
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Activin receptor type-1 | polymer | 301 | 34531.6 | 1 | UniProt (Q04771) Pfam (PF07714) | Homo sapiens (human) | Activin receptor type I,ACTR-I,Activin receptor-like kinase 2,ALK-2,Serine/threonine-protein kinase receptor R1,SKR1,TGF-B superfamily receptor type I,TSR-I |
| 2 | B (A) | 4-(1-ethyl-3-pyridin-3-yl-pyrazol-4-yl)-~{N}-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]pyrimidin-2-amine | non-polymer | 482.6 | 1 | Chemie (A1L4C) | |||
| 3 | C, D, E, F, G... (A) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 4 | I (A) | water | water | 18.0 | 112 | Chemie (HOH) |
Sequence modifications
A: 201 - 499 (UniProt: Q04771)
| PDB | External Database | Details |
|---|---|---|
| Ser 199 | - | expression tag |
| Met 200 | - | expression tag |
| His 206 | Arg 206 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34531.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1059.0 | |
| All* | Total formula weight | 35590.6 |
