9KVQ
Cryo-EM structure of SARS-CoV-2 BA.1 spike protein in complex with three-nAb 8H12, 3E2 and 1C4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Light chain of 3E2 | polymer | 104 | 11203.4 | 1 | Mus musculus | ||
| 2 | B (H) | Heavy chain of 3E2 | polymer | 121 | 13105.7 | 1 | Mus musculus | ||
| 3 | C (B) | Light chain of 8H12 | polymer | 107 | 11945.6 | 1 | Mus musculus | ||
| 4 | D (A) | Heavy chain of 8H12 | polymer | 119 | 13240.8 | 1 | Mus musculus | ||
| 5 | E (G) | Spike protein S1 | polymer | 194 | 22069.9 | 1 | UniProt (P0DTC2) Pfam (PF09408) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | |
| 6 | F (D) | Light chain of 1C4 | polymer | 107 | 11642.9 | 1 | Mus musculus | ||
| 7 | G (C) | Heavy chain of 1C4 | polymer | 119 | 13384.9 | 1 | Mus musculus | ||
| 8 | H (E) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) |
Sequence modifications
G: 333 - 526 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Asp 339 | Gly 339 | variant |
| Leu 371 | Ser 371 | variant |
| Pro 373 | Ser 373 | variant |
| Phe 375 | Ser 375 | variant |
| Asn 417 | Lys 417 | variant |
| Lys 440 | Asn 440 | variant |
| Ser 446 | Gly 446 | variant |
| Asn 477 | Ser 477 | variant |
| Lys 478 | Thr 478 | variant |
| Ala 484 | Glu 484 | variant |
| Arg 493 | Gln 493 | variant |
| Ser 496 | Gly 496 | variant |
| Arg 498 | Gln 498 | variant |
| Tyr 501 | Asn 501 | variant |
| His 505 | Tyr 505 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 96593.0 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| All* | Total formula weight | 97179.6 |
