9KVH

A Cryo_EM structure of 5_HT1A complex with TMT

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Guanine nucleotide-binding protein G(i) subunit alpha-1	polymer	354	40356.0	1	UniProt (P63096) Pfam (PF00503)	Homo sapiens (human)	Adenylate cyclase-inhibiting G alpha protein
2	B (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	344	37784.3	1	UniProt (P62873) Pfam (PF25391)	Homo sapiens (human)	Transducin beta chain 1
3	C (E)	SCFV16	polymer	247	26277.3	1		Homo sapiens (human)
4	D (G)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631)	Homo sapiens (human)	G gamma-I
5	E (R)	5-hydroxytryptamine receptor 1A	polymer	398	43859.3	1	UniProt (P08908) Pfam (PF00001)	Homo sapiens (human)	5-HT-1A,5-HT1A,G-21,Serotonin receptor 1A
6	F (R)	Cinobufotenine	non-polymer		219.3	1	Chemie (A1EG9)
7	G (R)	[(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5E,8E)-hexadeca-5,8,11,14-tetraenoate	non-polymer		854.9	1	Chemie (J40) PubChem (155884459) PubChem (171389934)
8	H (R)	GLYCOCHENODEOXYCHOLIC ACID	non-polymer		449.6	1	Chemie (CHO) PubChem (17753896) PubChem (22808456) PubChem (22833540) PubChem (44312819) PubChem (45052109) PubChem (46839357) PubChem (49874127) PubChem (16213700) PubChem (22808055) PubChem (53391261) PubChem (56606329) PubChem (53477907) PubChem (12544) PubChem (57696971) PubChem (27929) PubChem (58104997) PubChem (86312246) PubChem (86331068) PubChem (86310766) PubChem (90474429) PubChem (91746178) PubChem (91798922) PubChem (92450270) PubChem (97629473) PubChem (99564957) PubChem (124335016) PubChem (124784355) PubChem (124899320) PubChem (9933432) PubChem (70420975) PubChem (134692575) PubChem (134555903) PubChem (76329458) PubChem (12310291) PubChem (12310290) PubChem (86310768) PubChem (86312248) PubChem (86328252) PubChem (86331070) PubChem (93353) PubChem (440686) PubChem (94029808) PubChem (99564958) PubChem (99564959) PubChem (99566017) PubChem (118554507) PubChem (122361926) PubChem (124350391) PubChem (124350392) PubChem (124422684) PubChem (124899321) PubChem (124899323) PubChem (124902784) PubChem (124902786) PubChem (124902792) PubChem (124905412) PubChem (126963422) PubChem (126968461) PubChem (129317599) PubChem (131632351) PubChem (133109218) PubChem (133612048) PubChem (133688432) PubChem (10095257) PubChem (10389035) PubChem (10994028) PubChem (137349097) PubChem (139024238) PubChem (139291853) PubChem (139291854) PubChem (142492682) PubChem (12310284) PubChem (12310285) PubChem (12310287) PubChem (12310288) PubChem (159623905) PubChem (163025202) PubChem (163198935) PubChem (163337735) PubChem (175271619)
9	I (R)	CHOLESTEROL	non-polymer		386.7	1	Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (45044259) PubChem (49853509) PubChem (50990013) PubChem (176980071) PubChem (18640088) PubChem (52934537) PubChem (1715243) PubChem (1715244) PubChem (23423981) PubChem (44654663) PubChem (46937002) PubChem (56621683) PubChem (59274407) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (5997) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (1551269) PubChem (90070115) PubChem (59450329) PubChem (59628412) PubChem (117965027) PubChem (6432564) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (6710666) PubChem (124146240) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (10861996) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (132837164) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (304) PubChem (138967089) PubChem (139566851) PubChem (89951918) PubChem (90224410) PubChem (15939944) PubChem (91298236) PubChem (191463) PubChem (368063) PubChem (369319) PubChem (638019) PubChem (101624109) PubChem (1549081) PubChem (1553803) PubChem (171828367) PubChem (173516975) PubChem (124225449) PubChem (124429284) PubChem (5283629) PubChem (5284644) PubChem (5315842) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (6419195) PubChem (6994560) PubChem (130459183) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (131992107) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (11463329) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (139568882) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573)
10	J (R)	water	water		18.0	8	Chemie (HOH)

Sequence modifications

A: 1 - 354 (UniProt: P63096)

PDB	External Database	Details
Asn 47	Ser 47	conflict
Ala 203	Gly 203	conflict
Asp 236	Glu 236	conflict
Glu 237	Asp 237	conflict
Ala 238	Glu 238	conflict
Ala 245	Glu 245	conflict
Ser 326	Ala 326	conflict

B: 7 - 345 (UniProt: P62873)

PDB	External Database	Details
Gly 2	-	expression tag
Ser 3	-	expression tag
Leu 4	-	expression tag
Leu 5	-	expression tag
Gln 6	-	expression tag

R: 25 - 422 (UniProt: P08908)

PDB	External Database	Details
Trp 125	Leu 125	conflict

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	156138.0
Non-Polymers*	Number of molecules	4
	Total formula weight	1910.5
All*	Total formula weight	158048.5

*Water molecules are not included.