9KVF
Cryo-EM structure of SARS-CoV-2 EG.1 spike protein in complex with triple-nAb 4A5, 4C1 and 2E10
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 2E10 light chain | polymer | 110 | 11792.6 | 1 | Macaca mulatta | ||
| 2 | B (G) | Spike protein S1 | polymer | 284 | 31750.9 | 1 | UniProt (P0DTC2) Pfam (PF09408) Pfam (PF19209) | Severe acute respiratory syndrome coronavirus 2 | |
| 3 | C (F) | 4C1 heavy chain | polymer | 128 | 14201.6 | 1 | Macaca mulatta | ||
| 4 | D (E) | 4C1 light chain | polymer | 110 | 11531.5 | 1 | Macaca mulatta | ||
| 5 | E (B) | 2E10 heavy chain | polymer | 122 | 13308.9 | 1 | Macaca mulatta | ||
| 6 | F (C) | 4A5 heavy chain | polymer | 123 | 13542.3 | 1 | Macaca mulatta | ||
| 7 | G (D) | 4A5 light chain | polymer | 107 | 11665.9 | 1 | Macaca mulatta |
Sequence modifications
G: 317 - 600 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| His 339 | Gly 339 | variant |
| Thr 346 | Arg 346 | variant |
| Ile 368 | Leu 368 | variant |
| Phe 371 | Ser 371 | variant |
| Pro 373 | Ser 373 | variant |
| Phe 375 | Ser 375 | variant |
| Ala 376 | Thr 376 | variant |
| Asn 405 | Asp 405 | variant |
| Ser 408 | Arg 408 | variant |
| Asn 417 | Lys 417 | variant |
| Lys 440 | Asn 440 | variant |
| Pro 445 | Val 445 | variant |
| Ser 446 | Gly 446 | variant |
| Lys 460 | Asn 460 | variant |
| Asn 477 | Ser 477 | variant |
| Lys 478 | Thr 478 | variant |
| Ala 484 | Glu 484 | variant |
| Pro 486 | Phe 486 | variant |
| Ser 490 | Phe 490 | variant |
| Arg 498 | Gln 498 | variant |
| Tyr 501 | Asn 501 | variant |
| His 505 | Tyr 505 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 107793.6 | |
| All* | Total formula weight | 107793.6 |
