9KQV

Cryo-EM structure of MPXV core protease in complex with aloxistatin(E64d)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Core protease I7	polymer	423	49088.5	2	UniProt (Q5IXV7) Pfam (PF03290)	Monkeypox virus	I7L,MPXV-COP-062,MPXV-SL-062,MPXV-WRAIR062,MPXVgp068,Viral core cysteine proteinase,Virion core cysteine protease
2	C, D (A, B)	ethyl (3S)-3-hydroxy-4-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}amino)-4-oxobutanoate	non-polymer		344.4	2	Chemie (E6D)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	98177.0
Non-Polymers*	Number of molecules	2
	Total formula weight	688.9
All*	Total formula weight	98865.8

*Water molecules are not included.