9KQA

Cryo-EM structure of human VMAT2 in complex with Tetrabenazine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Soluble cytochrome b562,Synaptic vesicular amine transporter	polymer	632	69127.1	1	UniProt (P0ABE7) UniProt (Q05940) Pfam (PF07690)	Homo sapiens (human)	Cytochrome b-562,Monoamine transporter,Solute carrier family 18 member 2,Vesicular amine transporter 2,VAT2
2	B (A)	(3S,5R,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one	non-polymer		317.4	1	Chemie (EBZ)

Sequence modifications

A: -94 - 11 (UniProt: P0ABE7)

PDB	External Database	Details
Met -95	-	initiating methionine
Trp -88	Met 29	engineered mutation
Ile 7	His 124	engineered mutation
Leu 11	Arg 128	engineered mutation

A: 12 - 514 (UniProt: Q05940)

PDB	External Database	Details
His 515	-	expression tag
His 516	-	expression tag
His 517	-	expression tag
His 518	-	expression tag
His 519	-	expression tag
His 520	-	expression tag
His 521	-	expression tag
His 522	-	expression tag
His 523	-	expression tag
His 524	-	expression tag
Gly 525	-	expression tag
Ser 526	-	expression tag
Val 527	-	expression tag
Glu 528	-	expression tag
Asp 529	-	expression tag
Tyr 530	-	expression tag
Lys 531	-	expression tag
Asp 532	-	expression tag
Asp 533	-	expression tag
Asp 534	-	expression tag
Asp 535	-	expression tag
Lys 536	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	69127.1
Non-Polymers*	Number of molecules	1
	Total formula weight	317.4
All*	Total formula weight	69444.5

*Water molecules are not included.