9KQ8
Cryo-EM structure of human VMAT2 in complex with valbenazine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Soluble cytochrome b562,Synaptic vesicular amine transporter | polymer | 632 | 69127.1 | 1 | UniProt (P0ABE7) UniProt (Q05940) Pfam (PF07690) | Escherichia coli | Cytochrome b-562,Monoamine transporter,Solute carrier family 18 member 2,Vesicular amine transporter 2,VAT2 |
| 2 | B (A) | valbenazine | non-polymer | 418.6 | 1 | Chemie (XW7) PubChem (24795069) PubChem (24984318) PubChem (24984317) PubChem (59759829) PubChem (66824474) PubChem (66824475) PubChem (90701378) PubChem (118916012) PubChem (131632224) PubChem (118916011) PubChem (118922792) PubChem (118922800) PubChem (118922807) PubChem (124090735) PubChem (124630911) PubChem (124630912) PubChem (124635569) PubChem (129278993) PubChem (129279004) PubChem (134417209) PubChem (134692161) PubChem (137705931) PubChem (139034118) PubChem (140921015) PubChem (147623713) PubChem (155253337) PubChem (156596496) PubChem (169438658) PubChem (169438659) PubChem (169438660) PubChem (169438661) PubChem (171381957) |
Sequence modifications
A: -94 - 11 (UniProt: P0ABE7)
A: 12 - 514 (UniProt: Q05940)
| PDB | External Database | Details |
|---|---|---|
| Met -95 | - | initiating methionine |
| Trp -88 | Met 29 | engineered mutation |
| Ile 7 | His 124 | engineered mutation |
| Leu 11 | Arg 128 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| His 515 | - | expression tag |
| His 516 | - | expression tag |
| His 517 | - | expression tag |
| His 518 | - | expression tag |
| His 519 | - | expression tag |
| His 520 | - | expression tag |
| His 521 | - | expression tag |
| His 522 | - | expression tag |
| His 523 | - | expression tag |
| His 524 | - | expression tag |
| Gly 525 | - | expression tag |
| Ser 526 | - | expression tag |
| Val 527 | - | expression tag |
| Glu 528 | - | expression tag |
| Asp 529 | - | expression tag |
| Tyr 530 | - | expression tag |
| Lys 531 | - | expression tag |
| Asp 532 | - | expression tag |
| Asp 533 | - | expression tag |
| Asp 534 | - | expression tag |
| Asp 535 | - | expression tag |
| Lys 536 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 69127.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 418.6 | |
| All* | Total formula weight | 69545.6 |
