9KOF

Structure of human PRC2 with SAH and H3K27me3 peptide

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Histone-lysine N-methyltransferase EZH2	polymer	718	82266.5	1	UniProt (Q15910)	Homo sapiens (human)	ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6
2	B, D (C, E)	H3K27me3	polymer	7	743.9	2		Homo sapiens
3	C (D)	Polycomb protein EED	polymer	370	42913.7	1	UniProt (O75530)	Homo sapiens (human)	hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1
4	E (G)	Polycomb protein SUZ12	polymer	597	69661.2	1	UniProt (Q15022)	Homo sapiens (human)	Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog
5	F (F)	Zinc finger protein AEBP2	polymer	106	12236.2	1	UniProt (Q6ZN18)	Homo sapiens (human)	Adipocyte enhancer-binding protein 2,AE-binding protein 2
6	G (H)	Histone-binding protein RBBP4	polymer	407	45892.8	1	UniProt (Q09028)	Homo sapiens (human)	Chromatin assembly factor 1 subunit C,CAF-1 subunit C,Chromatin assembly factor I p48 subunit,CAF-I 48 kDa subunit,CAF-I p48,Nucleosome-remodeling factor subunit RBAP48,Retinoblastoma-binding protein 4,RBBP-4,Retinoblastoma-binding protein p48
7	H (A)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	1	Chemie (SAH) PubChem (439155)

Sequence modifications

D: 80 - 441 (UniProt: O75530)

PDB	External Database	Details
His 72	-	expression tag
His 73	-	expression tag
His 74	-	expression tag
His 75	-	expression tag
His 76	-	expression tag
His 77	-	expression tag
His 78	-	expression tag
His 79	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	254458.1
Non-Polymers*	Number of molecules	1
	Total formula weight	384.4
All*	Total formula weight	254842.6

*Water molecules are not included.