9KM6
The crystal structure of XhnM1 and its inhibitor sinefugin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Class I SAM-dependent methyltransferase | polymer | 304 | 32075.9 | 2 | UniProt (A0A3R7FZU3) Pfam (PF13649) | Streptomyces xinghaiensis | |
| 2 | C, I (A, B) | SINEFUNGIN | non-polymer | 381.4 | 2 | Chemie (SFG) PubChem (456189) PubChem (4065234) PubChem (6917665) PubChem (12771337) PubChem (25246236) PubChem (176612030) PubChem (177116271) PubChem (46875078) PubChem (46936257) PubChem (65482) PubChem (70789212) PubChem (93287274) PubChem (12771338) PubChem (70602121) PubChem (92403972) PubChem (93287270) PubChem (93287272) PubChem (93475589) PubChem (131971033) PubChem (131972810) PubChem (138626357) PubChem (156562738) PubChem (162866891) PubChem (163339130) PubChem (168280605) | |||
| 3 | D, J, K (A, B) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) PubChem (312) | |||
| 4 | E, F, G, H (A) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) PubChem (753) | |||
| 5 | L, M (A, B) | water | water | 18.0 | 251 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 283 (UniProt: A0A3R7FZU3)
| PDB | External Database | Details |
|---|---|---|
| Met -20 | - | initiating methionine |
| Gly -19 | - | expression tag |
| Ser -18 | - | expression tag |
| Ser -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Val -6 | - | expression tag |
| Pro -5 | - | expression tag |
| Arg -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
| Ala 215 | Val 215 | conflict |
| Val 240 | Ala 240 | conflict |
| Asp 264 | Glu 264 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64151.9 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1237.5 | |
| All* | Total formula weight | 65389.4 |
