9KLA
Crystal Structure of the bromodomain of human BRD9 in complex with the inhibitor Y22024
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bromodomain-containing protein 9 | polymer | 149 | 17433.3 | 1 | UniProt (Q9H8M2) Pfam (PF00439) | Homo sapiens (human) | Rhabdomyosarcoma antigen MU-RMS-40.8 |
| 2 | B, E (A) | 1-[1-(3,5-dimethoxyphenyl)indolizin-3-yl]ethanone | non-polymer | 295.3 | 2 | Chemie (A1EF0) | |||
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D (A) | D-MALATE | non-polymer | 134.1 | 1 | Chemie (MLT) | |||
| 5 | F (A) | water | water | 18.0 | 118 | Chemie (HOH) |
Sequence modifications
A: 134 - 239 (UniProt: Q9H8M2)
| PDB | External Database | Details |
|---|---|---|
| Met 111 | - | initiating methionine |
| Lys 112 | - | expression tag |
| Lys 113 | - | expression tag |
| Gly 114 | - | expression tag |
| His 115 | - | expression tag |
| His 116 | - | expression tag |
| His 117 | - | expression tag |
| His 118 | - | expression tag |
| His 119 | - | expression tag |
| His 120 | - | expression tag |
| Glu 121 | - | expression tag |
| Asn 122 | - | expression tag |
| Leu 123 | - | expression tag |
| Tyr 124 | - | expression tag |
| Phe 125 | - | expression tag |
| Gln 126 | - | expression tag |
| Gly 127 | - | expression tag |
| Gly 128 | - | expression tag |
| Ser 129 | - | expression tag |
| Leu 130 | - | expression tag |
| Lys 131 | - | expression tag |
| Leu 132 | - | expression tag |
| Ser 133 | - | expression tag |
| Glu 240 | - | expression tag |
| Arg 241 | - | expression tag |
| Leu 242 | - | expression tag |
| Leu 243 | - | expression tag |
| Ala 244 | - | expression tag |
| Leu 245 | - | expression tag |
| Lys 246 | - | expression tag |
| Arg 247 | - | expression tag |
| Ser 248 | - | expression tag |
| Met 249 | - | expression tag |
| Ser 250 | - | expression tag |
| Phe 251 | - | expression tag |
| Met 252 | - | expression tag |
| Gln 253 | - | expression tag |
| Asp 254 | - | expression tag |
| Met 255 | - | expression tag |
| Asp 256 | - | expression tag |
| Phe 257 | - | expression tag |
| Ser 258 | - | expression tag |
| Gln 259 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 17433.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 816.8 | |
| All* | Total formula weight | 18250.1 |
