9KDF
CryoEM structure of Calcineurin-fusion Human endothelin receptor type-B in complex with RES-701-3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Calcineurin-fusion endothelin receptor type-B | polymer | 908 | 102498.9 | 1 | Homo sapiens | ||
| 2 | B (F) | Peptidyl-prolyl cis-trans isomerase FKBP1B | polymer | 116 | 12771.5 | 1 | UniProt (P68106) Pfam (PF00254) | Homo sapiens (human) | PPIase FKBP1B,12.6 kDa FK506-binding protein,12.6 kDa FKBP,FKBP-12.6,FK506-binding protein 1B,FKBP-1B,Immunophilin FKBP12.6,Rotamase,h-FKBP-12 |
| 3 | C (A) | RES-701-3 | polymer | 16 | 2078.2 | 1 | Streptomyces venezuelae | ||
| 4 | D, E, F, G (R) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) PubChem (271) | |||
| 5 | H (R) | FE (III) ION | non-polymer | 55.8 | 1 | Chemie (FE) PubChem (29936) | |||
| 6 | I (R) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 7 | J (F) | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN | non-polymer | 804.0 | 1 | Chemie (FK5) PubChem (23377000) PubChem (177746942) PubChem (23308325) PubChem (23581796) PubChem (24978521) PubChem (54611630) PubChem (57206900) PubChem (44294761) PubChem (44314852) PubChem (403209) PubChem (439492) PubChem (59042420) PubChem (59111253) PubChem (59112447) PubChem (59118415) PubChem (44575549) PubChem (59746606) PubChem (46783859) PubChem (59917266) PubChem (59918741) PubChem (60086106) PubChem (46781577) PubChem (66509027) PubChem (66672804) PubChem (49874294) PubChem (71296869) PubChem (71316759) PubChem (71668407) PubChem (73265325) PubChem (57417278) PubChem (57892354) PubChem (57910335) PubChem (58584114) PubChem (59032416) PubChem (58946030) PubChem (59141120) PubChem (59049316) PubChem (59974193) PubChem (59993548) PubChem (60035606) PubChem (66709866) PubChem (67340654) PubChem (67626881) PubChem (68219140) PubChem (68712665) PubChem (69247758) PubChem (176478128) PubChem (89068341) PubChem (176856280) PubChem (177675132) PubChem (5372) PubChem (64779) PubChem (445643) PubChem (77906388) PubChem (89249909) PubChem (89545901) PubChem (89960652) PubChem (5353987) PubChem (145857191) PubChem (117646237) PubChem (6426916) PubChem (6436007) PubChem (6473866) PubChem (123552884) PubChem (5472317) PubChem (9832283) PubChem (9853905) PubChem (125039862) PubChem (9918805) PubChem (125136698) PubChem (125136697) PubChem (9963169) PubChem (129009965) PubChem (129010422) PubChem (130330191) PubChem (131676819) PubChem (6536850) PubChem (6610362) PubChem (6912836) PubChem (133562888) PubChem (133688365) PubChem (11556866) PubChem (134694629) PubChem (9940643) PubChem (12134936) PubChem (13006299) PubChem (137705868) PubChem (138106951) PubChem (138574020) PubChem (124511204) PubChem (140494820) PubChem (13819070) PubChem (140647114) PubChem (13819074) PubChem (13819069) PubChem (140893615) PubChem (13819073) PubChem (149048732) PubChem (125039860) PubChem (125039861) PubChem (125136699) PubChem (125136700) PubChem (160433486) PubChem (162711219) PubChem (163027397) PubChem (163027399) PubChem (163027400) PubChem (125182986) PubChem (126687738) PubChem (166023667) PubChem (168312998) PubChem (170277719) PubChem (171042252) PubChem (171360199) PubChem (172042935) PubChem (173882479) PubChem (129606865) PubChem (131668141) PubChem (137546410) PubChem (137546581) PubChem (138574025) PubChem (139032034) PubChem (140652196) PubChem (143265740) PubChem (144640477) PubChem (146323807) PubChem (156417380) PubChem (156528350) PubChem (160433487) PubChem (163027398) PubChem (163027401) PubChem (163027402) PubChem (167413568) PubChem (170997009) PubChem (171122179) PubChem (171137683) PubChem (171156312) PubChem (171322980) PubChem (171329370) PubChem (172634670) PubChem (175667550) |
Sequence modifications
F: 4 - 110 (UniProt: P68106)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
| His 111 | - | expression tag |
| His 112 | - | expression tag |
| His 113 | - | expression tag |
| His 114 | - | expression tag |
| His 115 | - | expression tag |
| His 116 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 117348.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1085.6 | |
| All* | Total formula weight | 118434.1 |
