9KDA

Cryo-EM structure of lipid-mediated dimer of human norepinephrine transporter NET in the presence of the antidepressant vilazodone in an inward-open state at resolution of 2.44 angstrom.

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Sodium-dependent noradrenaline transporter	polymer	629	70715.9	2	UniProt (P23975) Pfam (PF00209)	Homo sapiens (human)	Norepinephrine transporter,NET,Solute carrier family 6 member 2
2	C, N (A, B)	5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide	non-polymer		441.5	2	Chemie (YG7)
3	D, E, F, G, H... (A, B)	CHOLESTEROL	non-polymer		386.7	16	Chemie (CLR)
4	K, V (A, B)	[(2~{R})-1-[[(2~{S})-2,3-bis(oxidanyl)propoxy]-oxidanyl-phosphoryl]oxy-3-nonanoyloxy-propan-2-yl] decanoate	non-polymer		540.6	2	Chemie (A1EFM)
5	W, X (A, B)	water	water		18.0	10	Chemie (HOH)

Sequence modifications

A, B: 1 - 617 (UniProt: P23975)

PDB	External Database	Details
Met -11	-	initiating methionine
Asp -10	-	expression tag
Tyr -9	-	expression tag
Lys -8	-	expression tag
Asp -7	-	expression tag
Asp -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Lys -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	141431.8
Non-Polymers*	Number of molecules	20
	Total formula weight	8150.8
All*	Total formula weight	149582.5

*Water molecules are not included.