9KCO

Cryo-EM structure of FD4-bound alpha-synuclein MSA-like fibril

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (F, G, H, I, J...)	Alpha-synuclein	polymer	140	14564.2	12	UniProt (P37840) Pfam (PF01387)	Homo sapiens (human)	Ac a-synuclein,Non-A beta component of AD amyloid,Non-A4 component of amyloid precursor,NACP
2	M, N, O, P, Q... (G, H, I, J, K...)	(2~{R})-1-fluoranyl-3-[[2-[(~{E})-2-[5-[6-(methylamino)pyridin-3-yl]pyridin-2-yl]ethenyl]-1,3-benzothiazol-6-yl]oxy]propan-2-ol	non-polymer		436.5	12	Chemie (A1EFL)

Sequence modifications

F, G, H, I, J, K, L, M, N, O, P, Q: 1 - 140 (UniProt: P37840)

PDB	External Database	Details
Asp 51	Gly 51	engineered mutation
Thr 53	Ala 53	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	174770.1
Non-Polymers*	Number of molecules	12
	Total formula weight	5238.0
All*	Total formula weight	180008.1

*Water molecules are not included.