9KCM
Cryo-EM structure of human sodium pump E1003K complexed with NDRG3 and TMX2 in (2Na+)E1-AMPPCP state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Sodium/potassium-transporting ATPase subunit beta-3 | polymer | 279 | 31545.5 | 1 | UniProt (P54709) Pfam (PF00287) | Homo sapiens (human) | Sodium/potassium-dependent ATPase subunit beta-3,ATPB-3 |
| 2 | B (N) | Protein NDRG3 | polymer | 298 | 32907.5 | 1 | UniProt (Q9UGV2) Pfam (PF03096) | Homo sapiens (human) | N-myc downstream-regulated gene 3 protein |
| 3 | C (A) | Sodium/potassium-transporting ATPase subunit alpha-1 | polymer | 985 | 108781.0 | 1 | UniProt (P05023) Pfam (PF00690) Pfam (PF00122) Pfam (PF13246) Pfam (PF00689) | Homo sapiens (human) | Na(+)/K(+) ATPase alpha-1 subunit,Sodium pump subunit alpha-1 |
| 4 | D (T) | Thioredoxin-related transmembrane protein 2 | polymer | 296 | 34077.6 | 1 | UniProt (Q9Y320) Pfam (PF00085) | Homo sapiens (human) | Cell proliferation-inducing gene 26 protein,Thioredoxin domain-containing protein 14 |
| 5 | E (A) | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 1 | Chemie (ACP) | |||
| 6 | F, G (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 7 | H (A) | water | water | 18.0 | 20 | Chemie (HOH) |
Sequence modifications
A: 39 - 1023 (UniProt: P05023)
| PDB | External Database | Details |
|---|---|---|
| Lys 1003 | Glu 1003 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 207311.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 551.2 | |
| All* | Total formula weight | 207862.8 |
