9KB7

Cryo-EM structure of LGR4-RSPO2 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Leucine-rich repeat-containing G-protein coupled receptor 4	polymer	845	93372.0	1	UniProt (Q9BXB1)	Homo sapiens (human)	G-protein coupled receptor 48
2	B (B)	R-spondin-2	polymer	160	18953.7	1	UniProt (Q6UXX9)	Homo sapiens (human)	Roof plate-specific spondin-2,hRspo2

Sequence modifications

A: 1 - 822 (UniProt: Q9BXB1)

PDB	External Database	Details
Glu 823	-	expression tag
Asn 824	-	expression tag
Leu 825	-	expression tag
Tyr 826	-	expression tag
Phe 827	-	expression tag
Gln 828	-	expression tag
Gly 829	-	expression tag
Asp 830	-	expression tag
Tyr 831	-	expression tag
Lys 832	-	expression tag
Asp 833	-	expression tag
Asp 834	-	expression tag
Asp 835	-	expression tag
Asp 836	-	expression tag
Lys 837	-	expression tag
His 838	-	expression tag
His 839	-	expression tag
His 840	-	expression tag
His 841	-	expression tag
His 842	-	expression tag
His 843	-	expression tag
His 844	-	expression tag
His 845	-	expression tag

B: 1 - 143 (UniProt: Q6UXX9)

PDB	External Database	Details
Glu 144	-	expression tag
Asn 145	-	expression tag
Leu 146	-	expression tag
Tyr 147	-	expression tag
Phe 148	-	expression tag
Gln 149	-	expression tag
Gly 150	-	expression tag
His 151	-	expression tag
His 152	-	expression tag
His 153	-	expression tag
His 154	-	expression tag
His 155	-	expression tag
His 156	-	expression tag
His 157	-	expression tag
His 158	-	expression tag
His 159	-	expression tag
His 160	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	112325.8
All*	Total formula weight	112325.8

*Water molecules are not included.