9K9T

MPXV DNA polymerase in complex with CDV

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	DNA polymerase	polymer	1031	119837.0	1	UniProt (A0A7H0DN44) Pfam (PF08452) Pfam (PF03104) Pfam (PF08408) Pfam (PF00136)	Monkeypox virus
2	B (E)	DNA (38-MER)	polymer	38	11677.5	1		Monkeypox virus
3	C (P)	DNA (24-MER)	polymer	24	7392.8	1		Monkeypox virus
4	D (C)	DNA polymerase processivity factor component A20	polymer	426	49203.9	1	UniProt (Q5IXP2) Pfam (PF05941) UniProt (by SIFTS) (A0A7H0DNC0)	Monkeypox virus
5	E (B)	E4R	polymer	218	25107.7	1	UniProt (Q5IXS4) UniProt (by SIFTS) (M1LL92)	Monkeypox virus	MPXV-COP-095,MPXV-SL-095,MPXV-WRAIR095,MPXVgp101,Uracil-DNA glycosylase,Uracil-DNA glycosylase DNA polymerase,Uracil-DNA glycosylase interacts with A20R,DNA polymerase processivity factor

Sequence modifications

A: 1 - 1006 (UniProt: A0A7H0DN44)

PDB	External Database	Details
Met -24	-	initiating methionine
Trp -23	-	expression tag
Ser -22	-	expression tag
His -21	-	expression tag
Pro -20	-	expression tag
Gln -19	-	expression tag
Phe -18	-	expression tag
Glu -17	-	expression tag
Lys -16	-	expression tag
Gly -15	-	expression tag
Ser -14	-	expression tag
Gly -13	-	expression tag
Ser -12	-	expression tag
Trp -11	-	expression tag
Ser -10	-	expression tag
His -9	-	expression tag
Pro -8	-	expression tag
Gln -7	-	expression tag
Phe -6	-	expression tag
Glu -5	-	expression tag
Lys -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Phe 108	Leu 108	conflict
Ala 166	Asp 166	engineered mutation
Ala 168	Glu 168	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	213219.0
All*	Total formula weight	213219.0

*Water molecules are not included.