9K7E

Crystal structure of T2R-TTL-taccalonolide Y8 complex

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Detyrosinated tubulin alpha-1B chain	polymer	440	48966.3	2	UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953)	Sus scrofa (pig)
2	B, D (B, D)	Tubulin beta-2B chain	polymer	431	48391.4	2	UniProt (Q6B856) Pfam (PF00091) Pfam (PF03953)	Bos taurus (domestic cattle)
3	E (E)	Stathmin-4	polymer	143	16844.2	1	UniProt (P63043) Pfam (PF00836)	Rattus norvegicus (Norway rat)	Stathmin-like protein B3,RB3
4	F (F)	Tubulin--tyrosine ligase	polymer	380	43825.9	1	UniProt (A0A8C9FGJ1) Pfam (PF03133)	Gallus gallus (chicken)
5	G, O (A, C)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	2	Chemie (GTP)
6	H, P (A, C)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
7	I, N, Q (A, B, C)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
8	J (B)	(4~{R})-5-(4-hydroxyphenyl)-3-(4-methylphenyl)-4-phenyl-2,4-dihydropyrrolo[3,4-c]pyrazol-6-one	non-polymer		381.4	1	Chemie (A1EE1)
9	K, R (B, D)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
10	L, M (B)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	2	Chemie (MES)
11	S (F)	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER	non-polymer		505.2	1	Chemie (ACP)
12	T (B)	water	water		18.0	4	Chemie (HOH)

Sequence modifications

E: 5 - 145 (UniProt: P63043)

PDB	External Database	Details
Met 3	-	initiating methionine
Ala 4	-	expression tag

F: 1 - 378 (UniProt: A0A8C9FGJ1)

PDB	External Database	Details
His 379	-	expression tag
His 380	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	255385.5
Non-Polymers*	Number of molecules	13
	Total formula weight	3362.9
All*	Total formula weight	258748.5

*Water molecules are not included.