9K7E

Crystal structure of T2R-TTL-taccalonolide Y8 complex

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Detyrosinated tubulin alpha-1B chain	polymer	440	48966.3	2	UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953)	Sus scrofa (pig)
2	B, D (B, D)	Tubulin beta-2B chain	polymer	431	48391.4	2	UniProt (Q6B856) Pfam (PF00091) Pfam (PF03953)	Bos taurus (domestic cattle)
3	E (E)	Stathmin-4	polymer	143	16844.2	1	UniProt (P63043) Pfam (PF00836)	Rattus norvegicus (Norway rat)	Stathmin-like protein B3,RB3
4	F (F)	Tubulin--tyrosine ligase	polymer	380	43825.9	1	UniProt (A0A8C9FGJ1) Pfam (PF03133)	Gallus gallus (chicken)
5	G, O (A, C)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	2	Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466)
6	H, P (A, C)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA) PubChem (271)
7	I, N, Q (A, B, C)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG) PubChem (888)
8	J (B)	(4~{R})-5-(4-hydroxyphenyl)-3-(4-methylphenyl)-4-phenyl-2,4-dihydropyrrolo[3,4-c]pyrazol-6-one	non-polymer		381.4	1	Chemie (A1EE1)
9	K, R (B, D)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537)
10	L, M (B)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	2	Chemie (MES) PubChem (4478249)
11	S (F)	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER	non-polymer		505.2	1	Chemie (ACP) PubChem (4799) PubChem (46936826) PubChem (91532) PubChem (91885473) PubChem (157749842) PubChem (134943439) PubChem (157749839)
12	T (B)	water	water		18.0	4	Chemie (HOH)

Sequence modifications

E: 5 - 145 (UniProt: P63043)

PDB	External Database	Details
Met 3	-	initiating methionine
Ala 4	-	expression tag

F: 1 - 378 (UniProt: A0A8C9FGJ1)

PDB	External Database	Details
His 379	-	expression tag
His 380	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	255385.5
Non-Polymers*	Number of molecules	13
	Total formula weight	3362.9
All*	Total formula weight	258748.5

*Water molecules are not included.