9K6T
Cryo-EM Structure of hAGO2D669A-siRNA-target (21-nt)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein argonaute-2 | polymer | 859 | 97306.2 | 1 | UniProt (Q9UKV8) Pfam (PF16486) Pfam (PF08699) Pfam (PF02170) Pfam (PF16488) Pfam (PF16487) Pfam (PF02171) | Homo sapiens (human) | Argonaute2,hAgo2,Argonaute RISC catalytic component 2,Eukaryotic translation initiation factor 2C 2,eIF-2C 2,eIF2C 2,PAZ Piwi domain protein,PPD,Protein slicer |
| 2 | B (B) | RNA (5'-R(P*UP*AP*CP*AP*AP*GP*AP*GP*CP*CP*UP*UP*UP*CP*UP*GP*UP*UP*GP*UP*U)-3') | polymer | 21 | 6628.9 | 1 | Homo sapiens | ||
| 3 | C (C) | RNA (5'-R(P*AP*AP*CP*AP*AP*CP*AP*GP*AP*AP*AP*GP*GP*CP*UP*CP*UP*UP*GP*UP*U)-3') | polymer | 21 | 6721.1 | 1 | Homo sapiens | ||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
A: 1 - 859 (UniProt: Q9UKV8)
| PDB | External Database | Details |
|---|---|---|
| Ala 669 | Asp 669 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 110656.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 24.3 | |
| All* | Total formula weight | 110680.4 |
