9K3T
Cryo-EM structure of TMPRSS2 in complex with Fab fragments of 752 mAb and 2228 mAb
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Transmembrane protease serine 2 | polymer | 391 | 43250.6 | 1 | UniProt (O15393) Pfam (PF15494) Pfam (PF00089) | Homo sapiens (human) | Serine protease 10 |
| 2 | B (L) | Fab 752 light chain | polymer | 213 | 23749.3 | 1 | Mus musculus | ||
| 3 | C (H) | Fab 752 heavy chain | polymer | 229 | 24654.5 | 1 | Mus musculus | ||
| 4 | D (l) | Fab 2228 light chain | polymer | 218 | 23919.5 | 1 | Mus musculus | ||
| 5 | E (h) | Fab 2228 heavy chain | polymer | 230 | 24584.5 | 1 | Mus musculus |
Sequence modifications
A: 109 - 492 (UniProt: O15393)
| PDB | External Database | Details |
|---|---|---|
| Gly 108 | - | expression tag |
| Asp 250 | Ser 250 | engineered mutation |
| Asp 251 | Ser 251 | engineered mutation |
| Asp 252 | Arg 252 | engineered mutation |
| Asp 253 | Gln 253 | engineered mutation |
| Asp 254 | Ser 254 | engineered mutation |
| Lys 255 | Arg 255 | engineered mutation |
| Glu 493 | - | expression tag |
| Asn 494 | - | expression tag |
| Leu 495 | - | expression tag |
| Tyr 496 | - | expression tag |
| Phe 497 | - | expression tag |
| Gln 498 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 140158.4 | |
| All* | Total formula weight | 140158.4 |
