9K21
Cryo-EM structure of human taurine transporter TauT bound with homotaurine in an inward-open state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | Fragment antigen binding heavy chain | polymer | 118 | 13138.7 | 1 | Homo sapiens | ||
| 2 | B (L) | Fragment antigen binding light chain | polymer | 138 | 14920.1 | 1 | Homo sapiens | ||
| 3 | C (A) | Sodium- and chloride-dependent taurine transporter | polymer | 651 | 73446.3 | 1 | UniProt (P31641) Pfam (PF00209) | Homo sapiens (human) | Sodium- and chloride- dependent taurine transporter TauT,Solute carrier family 6 member 6 |
| 4 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | E (A) | 3-aminopropane-1-sulfonic acid | non-polymer | 139.2 | 1 | Chemie (A20) |
Sequence modifications
A: 1 - 620 (UniProt: P31641)
| PDB | External Database | Details |
|---|---|---|
| His 319 | Lys 319 | engineered mutation |
| Asn 320 | Tyr 320 | engineered mutation |
| Val 322 | Ser 322 | engineered mutation |
| Asn 486 | Asp 486 | engineered mutation |
| Arg 487 | Asn 487 | engineered mutation |
| Phe 488 | Leu 488 | engineered mutation |
| Ser 489 | Tyr 489 | engineered mutation |
| Glu 490 | Asp 490 | engineered mutation |
| Asp 491 | Gly 491 | engineered mutation |
| Arg 493 | Glu 493 | engineered mutation |
| Phe 498 | Tyr 498 | engineered mutation |
| Pro 499 | Arg 499 | engineered mutation |
| Gly 621 | - | expression tag |
| Ser 622 | - | expression tag |
| Asp 623 | - | expression tag |
| Glu 624 | - | expression tag |
| Val 625 | - | expression tag |
| Asp 626 | - | expression tag |
| Ala 627 | - | expression tag |
| Gly 628 | - | expression tag |
| Ser 629 | - | expression tag |
| His 630 | - | expression tag |
| His 631 | - | expression tag |
| His 632 | - | expression tag |
| His 633 | - | expression tag |
| His 634 | - | expression tag |
| His 635 | - | expression tag |
| His 636 | - | expression tag |
| His 637 | - | expression tag |
| His 638 | - | expression tag |
| His 639 | - | expression tag |
| Gly 640 | - | expression tag |
| Ser 641 | - | expression tag |
| Val 642 | - | expression tag |
| Glu 643 | - | expression tag |
| Asp 644 | - | expression tag |
| Tyr 645 | - | expression tag |
| Lys 646 | - | expression tag |
| Asp 647 | - | expression tag |
| Asp 648 | - | expression tag |
| Asp 649 | - | expression tag |
| Asp 650 | - | expression tag |
| Lys 651 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 101505.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 174.6 | |
| All* | Total formula weight | 101679.6 |
