9JS4

Cryo-EM structure of neutralizing antibody 8G3 in complex with BA.1 RBD

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Light chain of 8G3	polymer	217	23723.2	1		Homo sapiens
2	B (B)	Heavy chain of 8G3	polymer	222	23338.2	1		Homo heidelbergensis	Homo sapiens
3	C (C)	Spike glycoprotein	polymer	1233	137337.4	1	UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601)	Severe acute respiratory syndrome coronavirus (2019-nCoV SARS-CoV-2)	S glycoprotein,E2,Peplomer protein

Sequence modifications

C: 14 - 1207 (UniProt: P0DTC2)

PDB	External Database	Details
Val 65	Ala 67	variant
Ile 93	Thr 95	variant
Asp 143	Tyr 145	variant
Ile 209	-	insertion
Val 210	-	insertion
Arg 211	Asn 211	conflict
Glu 212	Leu 212	conflict
Pro 213	Val 213	conflict
Glu 214	Arg 214	variant
Asp 339	Gly 339	variant
Leu 371	Ser 371	variant
Pro 373	Ser 373	variant
Phe 375	Ser 375	variant
Asn 417	Lys 417	variant
Lys 440	Asn 440	variant
Ser 446	Gly 446	variant
Asn 477	Ser 477	variant
Lys 478	Thr 478	variant
Ala 484	Glu 484	variant
Arg 493	Gln 493	variant
Ser 496	Gly 496	variant
Arg 498	Gln 498	variant
Tyr 501	Asn 501	variant
His 505	Tyr 505	variant
Lys 547	Thr 547	variant
Gly 614	Asp 614	variant
Tyr 655	His 655	variant
Lys 679	Asn 679	variant
His 681	Pro 681	variant
Gly 682	Arg 682	conflict
Ser 683	Arg 683	conflict
Ser 685	Arg 685	conflict
Lys 764	Asn 764	variant
Tyr 796	Asp 796	variant
Pro 817	Phe 817	conflict
Lys 856	Asn 856	variant
Pro 892	Ala 892	conflict
Pro 899	Ala 899	conflict
Pro 942	Ala 942	conflict
His 954	Gln 954	variant
Lys 969	Asn 969	variant
Phe 981	Leu 981	variant
Pro 986	Lys 986	variant
Pro 987	Val 987	variant
Gln 1208	-	expression tag
Gly 1209	-	expression tag
Tyr 1210	-	expression tag
Ile 1211	-	expression tag
Pro 1212	-	expression tag
Glu 1213	-	expression tag
Ala 1214	-	expression tag
Pro 1215	-	expression tag
Arg 1216	-	expression tag
Asp 1217	-	expression tag
Gly 1218	-	expression tag
Gln 1219	-	expression tag
Ala 1220	-	expression tag
Tyr 1221	-	expression tag
Val 1222	-	expression tag
Arg 1223	-	expression tag
Lys 1224	-	expression tag
Asp 1225	-	expression tag
Gly 1226	-	expression tag
Glu 1227	-	expression tag
Trp 1228	-	expression tag
Val 1229	-	expression tag
Leu 1230	-	expression tag
Leu 1231	-	expression tag
Ser 1232	-	expression tag
Thr 1233	-	expression tag
Phe 1234	-	expression tag
Leu 1235	-	expression tag
Ala 1236	-	expression tag
His 1237	-	expression tag
His 1238	-	expression tag
His 1239	-	expression tag
His 1240	-	expression tag
His 1241	-	expression tag
His 1242	-	expression tag
His 1243	-	expression tag
His 1244	-	expression tag
His 1245	-	expression tag
His 1246	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	184398.8
All*	Total formula weight	184398.8

*Water molecules are not included.