9JRT
Structural Insights into Selective Antagonism of TG6-129 and EP2 Prostaglandin Receptor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GFP-like fluorescent chromoprotein,Prostaglandin E2 receptor EP2 subtype,Soluble cytochrome b562,Prostaglandin E2 receptor EP2 subtype,Soluble cytochrome b562 | polymer | 684 | 76678.4 | 1 | UniProt (P43116) UniProt (P0ABE7) | synthetic construct | prostaglandin E receptor EP2,PGE receptor EP2 subtype,PGE2 receptor EP2 subtype,Prostanoid EP2 receptor,Cytochrome b-562 |
| 2 | B (H) | Heavy chain of Fab fragment | polymer | 227 | 24153.0 | 1 | Mus musculus | ||
| 3 | C (N) | Nb | polymer | 122 | 13276.5 | 1 | synthetic construct | ||
| 4 | D (L) | Light chain of Fab fragment | polymer | 214 | 23398.1 | 1 | Mus musculus | ||
| 5 | E (A) | ~{N}-[[4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]carbamothioyl]-3-(4-fluorophenyl)propanamide | non-polymer | 493.6 | 1 | Chemie (A1EC5) |
Sequence modifications
A: -245 - 0 (PDB: 9JRT)
A: 1 - 224 (UniProt: P43116)
A: 230 - 328 (UniProt: P0ABE7)
A: 337 - 438 (UniProt: P43116)
A: 1 - 224 (UniProt: P43116)
A: 230 - 328 (UniProt: P0ABE7)
| PDB | External Database | Details |
|---|---|---|
| Trp 236 | Met 29 | conflict |
| - | Ala 65 | deletion |
| - | Thr 66 | deletion |
| - | Pro 67 | deletion |
| - | Pro 68 | deletion |
| - | Lys 69 | deletion |
| - | Leu 70 | deletion |
| - | Glu 71 | deletion |
| Gly 272 | Asp 72 | conflict |
| Gly 273 | Lys 73 | conflict |
| Gly 275 | - | insertion |
| Gly 276 | Pro 75 | conflict |
| Arg 277 | Asp 76 | conflict |
| Ile 325 | His 124 | conflict |
| Leu 329 | - | linker |
| Glu 330 | - | linker |
| Arg 331 | - | linker |
| Ala 332 | - | linker |
| Arg 333 | - | linker |
| Ser 334 | - | linker |
| Thr 335 | - | linker |
| Leu 336 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ala 225 | - | linker |
| Arg 226 | - | linker |
| Arg 227 | - | linker |
| Gln 228 | - | linker |
| Leu 229 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 137506.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 493.6 | |
| All* | Total formula weight | 137999.6 |
