9JRO

Structural Insights into Selective Antagonism of PF04418948 and EP2 Prostaglandin Receptor

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	Heavy chain of Fab fragment	polymer	227	24153.0	1		Mus musculus
2	B (L)	Light chain of Fab fragment	polymer	214	23398.1	1		Mus musculus
3	C (N)	Nb	polymer	122	13276.5	1		synthetic construct
4	D (A)	GFP-like fluorescent chromoprotein,Prostaglandin E2 receptor EP2 subtype,Soluble cytochrome b562,Prostaglandin E2 receptor EP2 subtype,Soluble cytochrome b562	polymer	684	76678.4	1	UniProt (P43116) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361)	synthetic construct	PGE receptor EP2 subtype,PGE2 receptor EP2 subtype,Prostanoid EP2 receptor,Cytochrome b-562
5	E (A)	1-(4-fluorophenyl)carbonyl-3-[(6-methoxynaphthalen-2-yl)oxymethyl]azetidine-3-carboxylic acid	non-polymer		409.4	1	Chemie (A1ECS)

Sequence modifications

A: -245 - 0 (PDB: 9JRO)
A: 1 - 224 (UniProt: P43116)
A: 230 - 328 (UniProt: P0ABE7)

PDB	External Database	Details
Trp 236	Met 29	conflict
-	Ala 65	deletion
-	Thr 66	deletion
-	Pro 67	deletion
-	Pro 68	deletion
-	Lys 69	deletion
-	Leu 70	deletion
-	Glu 71	deletion
Gly 272	Asp 72	conflict
Gly 273	Lys 73	conflict
Gly 275	-	insertion
Gly 276	Pro 75	conflict
Arg 277	Asp 76	conflict
Ile 325	His 124	conflict
Leu 329	-	linker
Glu 330	-	linker
Arg 331	-	linker
Ala 332	-	linker
Arg 333	-	linker
Ser 334	-	linker
Thr 335	-	linker
Leu 336	-	linker

A: 337 - 438 (UniProt: P43116)

PDB	External Database	Details
Ala 225	-	linker
Arg 226	-	linker
Arg 227	-	linker
Gln 228	-	linker
Leu 229	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	137506.0
Non-Polymers*	Number of molecules	1
	Total formula weight	409.4
All*	Total formula weight	137915.4

*Water molecules are not included.