9JR2

Cryo-EM structure of PTH-PTH1R-Gq (upright state)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Guanine nucleotide-binding protein G(q) subunit alpha-1 (miniGq)	polymer	245	27953.6	1	Pfam (PF00503) UniProt (by SIFTS) (P63092)	Homo sapiens
2	B (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	344	37799.3	1	UniProt (P54311) Pfam (PF00400)	Rattus rattus (black rat)	Transducin beta chain 1
3	C (G)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	67	7416.5	1	UniProt (P63212) Pfam (PF00631)	Bos taurus (domestic cattle)	G gamma-I
4	D (S)	scFv16	polymer	260	27720.8	1		Mus musculus
5	E (P)	Parathyroid hormone	polymer	35	4123.8	1	UniProt (P01270) Pfam (PF01279)	Homo sapiens	PTH,Parathormone,Parathyrin
6	F (R)	Parathyroid hormone/parathyroid hormone-related peptide receptor	polymer	567	63846.2	1	UniProt (Q03431) Pfam (PF02793) Pfam (PF00002)	Homo sapiens (human)	PTH/PTHrP type I receptor,PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTH1 receptor
7	G (R)	water	water		18.0	1	Chemie (HOH)

Sequence modifications

B: 2 - 340 (UniProt: P54311)

PDB	External Database	Details
Gly -3	-	expression tag
Ser -2	-	expression tag
Gln -1	-	expression tag
Leu 0	-	expression tag
Gln 1	-	expression tag

G: 2 - 67 (UniProt: P63212)

PDB	External Database	Details
Ser 68	-	expression tag

P: 1 - 34 (UniProt: P01270)

PDB	External Database	Details
Nh2 35	-	amidation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	168860.2
All*	Total formula weight	168860.2

*Water molecules are not included.