9JQZ
Structural Insights into Selective Antagonism Grapiprant and EP4 Prostaglandin Receptor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | Heavy chain of Fab fragment | polymer | 253 | 27574.1 | 1 | Mus musculus | ||
| 2 | B (A) | GFP-like fluorescent chromoprotein,Prostaglandin E2 receptor EP4 subtype | polymer | 549 | 61463.9 | 1 | UniProt (P35408) Pfam (PF00001) | synthetic construct | prostaglandin E receptor EP4,PGE receptor EP4 subtype,PGE2 receptor EP4 subtype,Prostanoid EP4 receptor |
| 3 | C (L) | Light chain of Fab fragment | polymer | 255 | 28944.3 | 1 | Mus musculus | ||
| 4 | D (A) | Grapiprant | non-polymer | 491.6 | 1 | Chemie (A1ECR) | |||
| 5 | E (A) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: -227 - -2 (PDB: 9JQZ)
A: -1 - 321 (UniProt: P35408)
A: -1 - 321 (UniProt: P35408)
| PDB | External Database | Details |
|---|---|---|
| Ala 0 | Thr 3 | engineered mutation |
| Gln 4 | Asn 7 | engineered mutation |
| Leu 59 | Ala 62 | engineered mutation |
| Arg 103 | Gly 106 | engineered mutation |
| Gln 174 | Asn 177 | engineered mutation |
| - | Met 218 | deletion |
| - | Arg 219 | deletion |
| - | Arg 220 | deletion |
| - | Thr 221 | deletion |
| - | Ser 222 | deletion |
| - | Leu 223 | deletion |
| - | Gly 224 | deletion |
| - | Thr 225 | deletion |
| - | Glu 226 | deletion |
| - | Gln 227 | deletion |
| - | His 228 | deletion |
| - | His 229 | deletion |
| - | Ala 230 | deletion |
| - | Ala 231 | deletion |
| - | Ala 232 | deletion |
| - | Ala 233 | deletion |
| - | Ala 234 | deletion |
| - | Ser 235 | deletion |
| - | Val 236 | deletion |
| - | Ala 237 | deletion |
| - | Ser 238 | deletion |
| - | Arg 239 | deletion |
| - | Gly 240 | deletion |
| - | His 241 | deletion |
| - | Pro 242 | deletion |
| - | Ala 243 | deletion |
| - | Ala 244 | deletion |
| - | Ser 245 | deletion |
| - | Pro 246 | deletion |
| - | Ala 247 | deletion |
| - | Leu 248 | deletion |
| - | Pro 249 | deletion |
| - | Arg 250 | deletion |
| - | Leu 251 | deletion |
| - | Ser 252 | deletion |
| - | Asp 253 | deletion |
| - | Phe 254 | deletion |
| - | Arg 255 | deletion |
| - | Arg 256 | deletion |
| - | Arg 257 | deletion |
| - | Arg 258 | deletion |
| - | Ser 259 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 117982.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 491.6 | |
| All* | Total formula weight | 118473.9 |
