9JMX
Crystal structure of IRED-M235A in complex with NADP+ and substrate
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 3-hydroxyisobutyrate dehydrogenase-like beta-hydroxyacid dehydrogenase | polymer | 286 | 30136.1 | 2 | UniProt (A0A3N2GPT5) Pfam (PF03446) Pfam (PF21761) | Amycolatopsis thermoflava | IRED |
| 2 | C, E (A, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 3 | D, F (A, B) | 1-~{tert}-butyl-4,9-dihydro-3~{H}-pyrido[3,4-b]indole | non-polymer | 226.3 | 2 | Chemie (A1ECB) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 193 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 286 (UniProt: A0A3N2GPT5)
| PDB | External Database | Details |
|---|---|---|
| Gly 59 | Glu 59 | conflict |
| Ala 83 | Thr 83 | conflict |
| Ala 106 | Thr 106 | conflict |
| Ala 235 | Met 235 | engineered mutation |
| Asp 264 | Glu 264 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 60272.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1939.4 | |
| All* | Total formula weight | 62211.7 |
