9JMD
Cryo-EM structure of the Azithromycin-Motilin receptor-Gq protein complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(q) subunit alpha | polymer | 361 | 41724.4 | 1 | Homo sapiens | ||
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37915.5 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (E) | ScFv16 | polymer | 247 | 26277.3 | 1 | Mus musculus | ||
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 70 | 7729.9 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (R) | Motilin receptor | polymer | 412 | 45392.2 | 1 | UniProt (O43193) Pfam (PF00001) | Homo sapiens (human) | G-protein coupled receptor 38 |
| 6 | F, G (R) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (304) PubChem (176980071) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (18640088) PubChem (1715243) PubChem (1715244) PubChem (45044259) PubChem (23423981) PubChem (49853509) PubChem (50990013) PubChem (52934537) PubChem (56621683) PubChem (191463) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (368063) PubChem (369319) PubChem (44654663) PubChem (59450329) PubChem (59628412) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (46937002) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (638019) PubChem (59274407) PubChem (1549081) PubChem (1553803) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (89951918) PubChem (90224410) PubChem (5997) PubChem (5283629) PubChem (5284644) PubChem (1551269) PubChem (90070115) PubChem (91298236) PubChem (5315842) PubChem (117965027) PubChem (6432564) PubChem (6710666) PubChem (124146240) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (6419195) PubChem (10861996) PubChem (132837164) PubChem (101624109) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (124225449) PubChem (138967089) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (139566851) PubChem (124429284) PubChem (11463329) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (15939944) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (171828367) PubChem (173516975) PubChem (130459183) PubChem (131992107) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) | |||
| 7 | H (R) | AZITHROMYCIN | non-polymer | 749.0 | 1 | Chemie (ZIT) PubChem (16757819) PubChem (20056474) PubChem (2269) PubChem (176529195) PubChem (71190996) PubChem (23304247) PubChem (71191184) PubChem (177594943) PubChem (25235496) PubChem (16413916) PubChem (21733141) PubChem (23229892) PubChem (22869773) PubChem (45357541) PubChem (71211241) PubChem (51371100) PubChem (53477736) PubChem (57793951) PubChem (44452787) PubChem (44317861) PubChem (58593561) PubChem (58613197) PubChem (58647134) PubChem (58649002) PubChem (58816759) PubChem (58984289) PubChem (71206930) PubChem (44661448) PubChem (45482397) PubChem (59856260) PubChem (59910644) PubChem (59982920) PubChem (60054509) PubChem (60086514) PubChem (71206984) PubChem (49849544) PubChem (71094687) PubChem (447043) PubChem (56845505) PubChem (57149533) PubChem (57765354) PubChem (58652532) PubChem (58756473) PubChem (58668032) PubChem (58846526) PubChem (58846527) PubChem (59022407) PubChem (59075891) PubChem (59771745) PubChem (59985602) PubChem (60052040) PubChem (176519926) PubChem (55185) PubChem (70908014) PubChem (71066582) PubChem (73265194) PubChem (456416) PubChem (89802855) PubChem (89969202) PubChem (89970527) PubChem (3086605) PubChem (91466261) PubChem (91486800) PubChem (71120102) PubChem (90489754) PubChem (90927984) PubChem (90989076) PubChem (6324605) PubChem (124604982) PubChem (124821849) PubChem (124761724) PubChem (124761726) PubChem (125180820) PubChem (126603997) PubChem (126969870) PubChem (129255978) PubChem (129313115) PubChem (129264255) PubChem (129396765) PubChem (129428544) PubChem (129830452) PubChem (10952758) PubChem (131887698) PubChem (11104628) PubChem (133109198) PubChem (133588153) PubChem (133556211) PubChem (11969951) PubChem (138105984) PubChem (10771356) PubChem (11029030) PubChem (13326587) PubChem (140919655) PubChem (124721102) PubChem (124721103) PubChem (124721104) PubChem (124721105) PubChem (124761720) PubChem (124761721) PubChem (124761722) PubChem (124761723) PubChem (124761725) PubChem (124761727) PubChem (145948753) PubChem (124821850) PubChem (124821851) PubChem (124821852) PubChem (124894582) PubChem (124894583) PubChem (124894584) PubChem (148533668) PubChem (154825141) PubChem (156588285) PubChem (159644379) PubChem (166639262) PubChem (166666711) PubChem (168138115) PubChem (171114714) PubChem (171114697) PubChem (171360714) PubChem (129009944) PubChem (129010025) PubChem (129010374) PubChem (173722062) PubChem (176093648) PubChem (129428530) PubChem (129428531) PubChem (129428532) PubChem (129627814) PubChem (131845181) PubChem (132199928) PubChem (132274083) PubChem (133562860) PubChem (134693946) PubChem (134693958) PubChem (134750426) PubChem (137704936) PubChem (142181598) PubChem (156853354) PubChem (157454801) PubChem (159644380) PubChem (159644381) PubChem (159644382) PubChem (171156713) PubChem (175970442) | |||
| 8 | I (R) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
B: 7 - 345 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Leu 4 | - | expression tag |
| Leu 5 | - | expression tag |
| Gln 6 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 159039.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1522.3 | |
| All* | Total formula weight | 160561.6 |
