9JH6

Activation mechanism of CYSLTR2 by C20:0

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (R)	Cysteinyl leukotriene receptor 2	polymer	346	39662.2	1	UniProt (Q9NS75) Pfam (PF00001)	Homo sapiens (human)	CysLTR2,G-protein coupled receptor GPCR21,hGPCR21,G-protein coupled receptor HG57,HPN321
2	B (C)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	59	6504.4	1	UniProt (P59768) Pfam (PF00631)	Homo sapiens (human)	G gamma-I
3	C (S)	scFv16	polymer	250	26640.6	1		Homo sapiens
4	D (A)	Guanine nucleotide-binding protein G(i) subunit alpha-1	polymer	361	41724.4	1		Homo sapiens
5	E (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	358	39489.2	1	UniProt (P62873) Pfam (PF00400)	Homo sapiens (human)	Transducin beta chain 1
6	F (N)	Nb35	polymer	151	16228.4	1		Lama glama
7	G (R)	Cer(d18:0/20:0)	non-polymer		596.0	1	Chemie (A1LXR)

Sequence modifications

R: 1 - 346 (UniProt: Q9NS75)

PDB	External Database	Details
Phe 193	Tyr 193	engineered mutation

B: 2 - 340 (UniProt: P62873)

PDB	External Database	Details
Met -17	-	initiating methionine
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Leu -10	-	expression tag
Glu -9	-	expression tag
Val -8	-	expression tag
Leu -7	-	expression tag
Phe -6	-	expression tag
Gln -5	-	expression tag
Gly -4	-	expression tag
Pro -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag
Gln 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	170249.2
Non-Polymers*	Number of molecules	1
	Total formula weight	596.0
All*	Total formula weight	170845.2

*Water molecules are not included.