9JEQ
Cryo-EM structure of Histamine-bound Histamine receptor 3 H3R G protein complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 339 | 37285.7 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 2 | B (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 58 | 6375.3 | 1 | UniProt (P63212) Pfam (PF00631) | Bos taurus (domestic cattle) | G gamma-I |
| 3 | C (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 352 | 40225.8 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 4 | D (R) | Histamine H3 receptor | polymer | 445 | 48708.2 | 1 | UniProt (Q9Y5N1) Pfam (PF00001) | Homo sapiens (human) | H3R,HH3R,G-protein coupled receptor 97 |
| 5 | E (S) | ScFv16 | polymer | 251 | 26679.7 | 1 | Mus musculus | ||
| 6 | F (R) | HISTAMINE | non-polymer | 111.1 | 1 | Chemie (HSM) |
Sequence modifications
A: 3 - 354 (UniProt: P63096)
R: 1 - 445 (UniProt: Q9Y5N1)
| PDB | External Database | Details |
|---|---|---|
| Asn 47 | Ser 47 | conflict |
| Ala 203 | Gly 203 | conflict |
| Ala 245 | Glu 245 | conflict |
| Ser 326 | Ala 326 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asn 146 | Gln 146 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 159274.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 111.1 | |
| All* | Total formula weight | 159385.9 |
