9JED
Cryo-EM structure of Histamine-bound Histamine receptor 4 H4R G protein complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 352 | 40225.8 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 339 | 37285.7 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 58 | 6375.3 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (R) | Histamine H4 receptor | polymer | 390 | 44543.8 | 1 | UniProt (Q9H3N8) Pfam (PF00001) | Homo sapiens (human) | H4R,HH4R,AXOR35,G-protein coupled receptor 105,GPRv53,Pfi-013,SP9144 |
| 5 | E (S) | ScFv16 | polymer | 247 | 26277.3 | 1 | Mus musculus | ||
| 6 | F (R) | HISTAMINE | non-polymer | 111.1 | 1 | Chemie (HSM) | |||
| 7 | G (R) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 8 | H (R) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A: 3 - 354 (UniProt: P63096)
| PDB | External Database | Details |
|---|---|---|
| Asn 47 | Ser 47 | conflict |
| Ala 203 | Gly 203 | conflict |
| Ala 245 | Glu 245 | conflict |
| Ser 326 | Ala 326 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 154707.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 206.1 | |
| All* | Total formula weight | 154914.0 |
