9JDU
The crystal structure of PDE10A complexed with inhibitor 2061
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 322 | 37292.0 | 2 | UniProt (Q9Y233) | Homo sapiens (human) | |
| 2 | C, F (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, G (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, H (A, B) | ethyl 2-[1-[4-[2-(diethylaminomethylamino)ethanoyl]quinolin-2-yl]azetidin-3-yl]imidazo[1,2-a]pyridine-3-carboxylate | non-polymer | 514.6 | 2 | Chemie (A1EBE) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 135 | Chemie (HOH) |
Sequence modifications
A, B: 449 - 769 (UniProt: Q9Y233)
| PDB | External Database | Details |
|---|---|---|
| Met 448 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74584.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1208.7 | |
| All* | Total formula weight | 75792.7 |
