9JD5

Cryo-EM structure of human TauT in presence of Taurocyamine, determined in an inward-facing occluded conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Sodium- and chloride-dependent taurine transporter	polymer	606	68496.0	1	UniProt (P31641) Pfam (PF00209)	Homo sapiens (human)	Solute carrier family 6 member 6
2	B, C, D (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
3	E, F (A)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
4	G (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
5	H, I, J (A)	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	3	Chemie (Y01)
6	K (A)	Taurocyamine	non-polymer		167.2	1	Chemie (3S5)
7	L (A)	water	water		18.0	1	Chemie (HOH)

Sequence modifications

A: 1 - 582 (UniProt: P31641)

PDB	External Database	Details
Ser 583	-	expression tag
Arg 584	-	expression tag
Leu 585	-	expression tag
Glu 586	-	expression tag
Glu 587	-	expression tag
Glu 588	-	expression tag
Leu 589	-	expression tag
Arg 590	-	expression tag
Arg 591	-	expression tag
Arg 592	-	expression tag
Thr 593	-	expression tag
Glu 594	-	expression tag
Pro 595	-	expression tag
Gly 596	-	expression tag
Leu 597	-	expression tag
Arg 598	-	expression tag
Ser 599	-	expression tag
Arg 600	-	expression tag
Leu 601	-	expression tag
Glu 602	-	expression tag
Val 603	-	expression tag
Leu 604	-	expression tag
Phe 605	-	expression tag
Gln 606	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	68496.0
Non-Polymers*	Number of molecules	10
	Total formula weight	2372.4
All*	Total formula weight	70868.4

*Water molecules are not included.