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9JBG

Cryo-EM structure of the human LYCHOS in complex with lipids in the expanded state

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Lysosomal cholesterol signaling proteinpolymer87898033.82UniProt (Q7Z3F1)Homo sapiens (human)LYCHOS,G-protein coupled receptor PGR22
2C, D, H
(A, B)
1,2-Distearoyl-sn-glycerophosphoethanolaminenon-polymer748.13Chemie (3PE)
3E
(A)
O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serinenon-polymer792.11Chemie (P5S)
4F
(B)
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINEnon-polymer790.11Chemie (PC1)
5G
(B)
OLEIC ACIDnon-polymer282.51Chemie (OLA)
Sequence modifications
A, B: 1 - 870 (UniProt: Q7Z3F1)
PDBExternal DatabaseDetails
Ser 871-expression tag
Arg 872-expression tag
Glu 873-expression tag
Asn 874-expression tag
Leu 875-expression tag
Tyr 876-expression tag
Phe 877-expression tag
Gln 878-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight196067.6
Non-Polymers*Number of molecules6
Total formula weight4108.9
All*Total formula weight200176.5
*Water molecules are not included.

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PDB entries from 2025-07-16

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