9JBG
Cryo-EM structure of the human LYCHOS in complex with lipids in the expanded state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Lysosomal cholesterol signaling protein | polymer | 878 | 98033.8 | 2 | UniProt (Q7Z3F1) Pfam (PF03547) Pfam (PF00610) | Homo sapiens (human) | LYCHOS,G-protein coupled receptor PGR22 |
| 2 | C, D, H (A, B) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 3 | Chemie (3PE) | |||
| 3 | E (A) | O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine | non-polymer | 792.1 | 1 | Chemie (P5S) | |||
| 4 | F (B) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 1 | Chemie (PC1) | |||
| 5 | G (B) | OLEIC ACID | non-polymer | 282.5 | 1 | Chemie (OLA) |
Sequence modifications
A, B: 1 - 870 (UniProt: Q7Z3F1)
| PDB | External Database | Details |
|---|---|---|
| Ser 871 | - | expression tag |
| Arg 872 | - | expression tag |
| Glu 873 | - | expression tag |
| Asn 874 | - | expression tag |
| Leu 875 | - | expression tag |
| Tyr 876 | - | expression tag |
| Phe 877 | - | expression tag |
| Gln 878 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 196067.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 4108.9 | |
| All* | Total formula weight | 200176.5 |
