9J8Z
Cryo-EM structure of human HCAR1-Gi complex without ligand (apo state)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 337 | 37069.5 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | |
| 2 | B (C) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 351 | 40153.7 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 56 | 6218.2 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (S) | scFv16 | polymer | 248 | 26424.4 | 1 | Homo sapiens (human) | ||
| 5 | E (A) | Hydroxycarboxylic acid receptor 1 | polymer | 279 | 31596.5 | 1 | UniProt (Q9BXC0) Pfam (PF00001) | Homo sapiens (human) | G-protein coupled receptor 104,G-protein coupled receptor 81 |
Sequence modifications
C: 4 - 354 (UniProt: P63096)
| PDB | External Database | Details |
|---|---|---|
| Ala 203 | Gly 203 | conflict |
| Ser 326 | Ala 326 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 141462.3 | |
| All* | Total formula weight | 141462.3 |
