9J84
Structureal mechanism of human TRPM3 ion channel inhibition
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Maltose/maltodextrin-binding periplasmic protein,Transient receptor potential cation channel subfamily M member 3 | polymer | 1610 | 183408.5 | 4 | UniProt (P0AEX9) UniProt (Q9HCF6) Pfam (PF18139) Pfam (PF25508) Pfam (PF00520) Pfam (PF16519) | Escherichia coli K-12 | MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,Long transient receptor potential channel 3,LTrpC-3,LTrpC3,Melastatin-2,MLSN2 |
| 2 | E, F, G, H (A, B, C, D) | ~{N}-[(3~{S})-3-(hydroxymethyl)piperidin-3-yl]-6-[(4-methyl-1,3-thiazol-5-yl)methoxy]-2,3-dihydro-1,4-benzoxazine-4-carboxamide | non-polymer | 418.5 | 4 | Chemie (A1EA5) |
Sequence modifications
A, B, C, D: -271 - 94 (UniProt: P0AEX9)
A, B, C, D: 121 - 1320 (UniProt: Q9HCF6)
| PDB | External Database | Details |
|---|---|---|
| Ala -289 | - | expression tag |
| Thr -288 | - | expression tag |
| Met -287 | - | expression tag |
| Gly -286 | - | expression tag |
| Met -285 | - | expression tag |
| Gly -284 | - | expression tag |
| Ser -283 | - | expression tag |
| Ser -282 | - | expression tag |
| His -281 | - | expression tag |
| His -280 | - | expression tag |
| His -279 | - | expression tag |
| His -278 | - | expression tag |
| His -277 | - | expression tag |
| His -276 | - | expression tag |
| Gly -275 | - | expression tag |
| Ser -274 | - | expression tag |
| Ser -273 | - | expression tag |
| Met -272 | - | expression tag |
| Asn 95 | - | linker |
| Ser 96 | - | linker |
| Ser 97 | - | linker |
| Ser 98 | - | linker |
| Asn 99 | - | linker |
| Asn 100 | - | linker |
| Asn 101 | - | linker |
| Asn 102 | - | linker |
| Asn 103 | - | linker |
| Asn 104 | - | linker |
| Asn 105 | - | linker |
| Asn 106 | - | linker |
| Asn 107 | - | linker |
| Asn 108 | - | linker |
| Leu 109 | - | linker |
| Gly 110 | - | linker |
| Ile 111 | - | linker |
| Glu 112 | - | linker |
| Leu 113 | - | linker |
| Glu 114 | - | linker |
| Val 115 | - | linker |
| Leu 116 | - | linker |
| Phe 117 | - | linker |
| Gln 118 | - | linker |
| Gly 119 | - | linker |
| Pro 120 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 733633.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1674.0 | |
| All* | Total formula weight | 735307.9 |
