9J6O

Crystal Structure of bromodomain of human CBP in complex with the inhibitor CZL-046

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	CREB-binding protein	polymer	133	15891.3	1	UniProt (Q92793) Pfam (PF00439)	Homo sapiens (human)
2	B (A)	(3~{S},5~{S})-1-[3,4-bis(fluoranyl)phenyl]-5-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(4-methoxycyclohexyl)benzimidazol-2-yl]-3-fluoranyl-pyrrolidin-2-one	non-polymer		538.6	1	Chemie (A1L3S)
3	C (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)

Sequence modifications

A: 1081 - 1197 (UniProt: Q92793)

PDB	External Database	Details
Met 1065	-	expression tag
Lys 1066	-	expression tag
Lys 1067	-	expression tag
Gly 1068	-	expression tag
His 1069	-	expression tag
His 1070	-	expression tag
His 1071	-	expression tag
His 1072	-	expression tag
His 1073	-	expression tag
His 1074	-	expression tag
Leu 1075	-	expression tag
Val 1076	-	expression tag
Pro 1077	-	expression tag
Arg 1078	-	expression tag
Gly 1079	-	expression tag
Ser 1080	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	15891.3
Non-Polymers*	Number of molecules	2
	Total formula weight	574.0
All*	Total formula weight	16465.3

*Water molecules are not included.