9J6H
Complex I from respirasome closed state 1 bound by metformin and CoQ10 (SC-MetC1-iv)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (4L) | NADH-ubiquinone oxidoreductase chain 4L | polymer | 98 | 10827.3 | 1 | UniProt (P56632) | Sus scrofa (pig) | NADH dehydrogenase subunit 4L |
| 2 | B (A1) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | polymer | 70 | 8034.4 | 1 | UniProt (K7GR43) | Sus scrofa (pig) | Complex I-MWFE,NADH-ubiquinone oxidoreductase MWFE subunit |
| 3 | C (A2) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | polymer | 85 | 9770.2 | 1 | UniProt (F1RGE3) | Sus scrofa (pig) | |
| 4 | D (A3) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | polymer | 83 | 9094.4 | 1 | UniProt (A0A4X1VPG4) | Sus scrofa (pig) | Complex I-B9,NADH-ubiquinone oxidoreductase B9 subunit |
| 5 | E (A5) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | polymer | 112 | 12949.1 | 1 | UniProt (A0A8D1IJ52) | Sus scrofa (pig) | |
| 6 | F (A6) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | polymer | 114 | 13755.9 | 1 | UniProt (F1SJP6) | Sus scrofa (pig) | Complex I-B14,NADH-ubiquinone oxidoreductase B14 subunit |
| 7 | G (A7) | Complex I-B14.5a | polymer | 112 | 12517.4 | 1 | UniProt (A0A4X1VLA2) | Sus scrofa (pig) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7,NADH-ubiquinone oxidoreductase subunit B14.5a |
| 8 | H (A8) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | polymer | 171 | 19932.9 | 1 | UniProt (F1SLR1) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase 19 kDa subunit,Complex I-19kD |
| 9 | I (A9) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | polymer | 341 | 38840.9 | 1 | UniProt (F1SL07) | Sus scrofa (pig) | Complex I-39kD,NADH-ubiquinone oxidoreductase 39 kDa subunit |
| 10 | J, K (AB, AC) | Acyl carrier protein | polymer | 87 | 10046.5 | 2 | UniProt (A0A287AAR5) | Sus scrofa (pig) | |
| 11 | L (AK) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | polymer | 321 | 36949.9 | 1 | UniProt (F1SIS9) | Sus scrofa (pig) | |
| 12 | M (AL) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 | polymer | 140 | 14555.7 | 1 | UniProt (I3LGM4) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase subunit B14.7,Complex I-B14.7 |
| 13 | N (AM) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | polymer | 144 | 17031.2 | 1 | UniProt (F1SQP4) | Sus scrofa (pig) | |
| 14 | O (AN) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | polymer | 142 | 16709.3 | 1 | UniProt (A0A8D1NRT6) | Sus scrofa (pig) | |
| 15 | P (B1) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | polymer | 56 | 6781.9 | 1 | UniProt (A0A8D2CGH8) | Sus scrofa (pig) | Complex I-MNLL,NADH-ubiquinone oxidoreductase MNLL subunit |
| 16 | Q (B2) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial | polymer | 67 | 8201.1 | 1 | UniProt (A0A5G2QW32) | Sus scrofa (pig) | Complex I-AGGG,NADH-ubiquinone oxidoreductase AGGG subunit |
| 17 | R (B3) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | polymer | 80 | 9042.2 | 1 | UniProt (A0A4X1VD84) | Sus scrofa (pig) | Complex I-B12,NADH-ubiquinone oxidoreductase B12 subunit |
| 18 | S (B4) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | polymer | 128 | 14986.2 | 1 | UniProt (A0A4X1T6M0) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase B15 subunit,Complex I-B15 |
| 19 | T (B5) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial | polymer | 138 | 16281.9 | 1 | UniProt (F1SGC6) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase SGDH subunit,Complex I-SGDH |
| 20 | U (B6) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | polymer | 126 | 15333.8 | 1 | UniProt (A0A480KM09) | Sus scrofa (pig) | Complex I-B17,NADH-ubiquinone oxidoreductase B17 subunit |
| 21 | V (B7) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | polymer | 125 | 15307.6 | 1 | UniProt (F1SCH1) | Sus scrofa (pig) | Complex I-B18,NADH-ubiquinone oxidoreductase B18 subunit |
| 22 | W (B8) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | polymer | 156 | 18608.8 | 1 | UniProt (F1RWL7) | Sus scrofa (pig) | Complex I-ASHI,NADH-ubiquinone oxidoreductase ASHI subunit |
| 23 | X (B9) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | polymer | 178 | 21733.7 | 1 | UniProt (K7GSE5) | Sus scrofa (pig) | Complex I-B22,NADH-ubiquinone oxidoreductase B22 subunit |
| 24 | Y (BK) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | polymer | 176 | 20944.8 | 1 | UniProt (I3LDC3) | Sus scrofa (pig) | |
| 25 | Z (BL) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | polymer | 102 | 12113.5 | 1 | UniProt (A0A8D1EYI7) | Sus scrofa (pig) | Complex I-ESSS,NADH-ubiquinone oxidoreductase ESSS subunit |
| 26 | AA (CA) | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | polymer | 49 | 5881.8 | 1 | UniProt (A1XQS6) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase KFYI subunit,Complex I-KFYI |
| 27 | BA (CB) | NADH dehydrogenase [ubiquinone] 1 subunit C2 | polymer | 121 | 14196.5 | 1 | UniProt (A0A480JRW3) | Sus scrofa (pig) | |
| 28 | CA (N1) | NADH-ubiquinone oxidoreductase chain 1 | polymer | 318 | 35667.5 | 1 | UniProt (O79874) | Sus scrofa (pig) | NADH dehydrogenase subunit 1 |
| 29 | DA (N2) | NADH-ubiquinone oxidoreductase chain 2 | polymer | 347 | 39077.5 | 1 | UniProt (O79875) | Sus scrofa (pig) | NADH dehydrogenase subunit 2 |
| 30 | EA (N3) | NADH-ubiquinone oxidoreductase chain 3 | polymer | 115 | 12998.4 | 1 | UniProt (O79880) | Sus scrofa (pig) | NADH dehydrogenase subunit 3 |
| 31 | FA (N4) | NADH-ubiquinone oxidoreductase chain 4 | polymer | 459 | 51853.4 | 1 | UniProt (Q7IIB7) | Sus scrofa (pig) | |
| 32 | GA (N5) | NADH-ubiquinone oxidoreductase chain 5 | polymer | 603 | 68267.0 | 1 | UniProt (Q71K68) | Sus scrofa (pig) | |
| 33 | HA (N6) | NADH-ubiquinone oxidoreductase chain 6 | polymer | 174 | 18890.1 | 1 | UniProt (O79882) | Sus scrofa (pig) | NADH dehydrogenase subunit 6 |
| 34 | IA (S1) | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | polymer | 689 | 75683.7 | 1 | UniProt (A0A4X1V1H9) | Sus scrofa (pig) | |
| 35 | JA (S2) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | polymer | 430 | 49234.3 | 1 | UniProt (F1S1A8) | Sus scrofa (pig) | Complex I-49kD,NADH-ubiquinone oxidoreductase 49 kDa subunit |
| 36 | KA (S3) | Complex I-30kD | polymer | 208 | 24521.7 | 1 | UniProt (A0A286ZNN4) | Sus scrofa (pig) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3,mitochondrial,NADH-ubiquinone oxidoreductase 30 kDa subunit |
| 37 | LA (S4) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | polymer | 124 | 14314.3 | 1 | UniProt (A0A4X1SN37) | Sus scrofa (pig) | Complex I-18 kDa,NADH-ubiquinone oxidoreductase 18 kDa subunit |
| 38 | MA (S5) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | polymer | 105 | 12375.4 | 1 | UniProt (F1SV23) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase 15 kDa subunit,Complex I-15 kDa |
| 39 | NA (S6) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | polymer | 96 | 10567.6 | 1 | UniProt (F1S031) | Sus scrofa (pig) | |
| 40 | OA (S7) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | polymer | 156 | 17875.0 | 1 | UniProt (A0A8D1TL60) | Sus scrofa (pig) | Complex I-20kD,NADH-ubiquinone oxidoreductase 20 kDa subunit |
| 41 | PA (S8) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | polymer | 176 | 20208.0 | 1 | UniProt (A0A287BDC0) | Sus scrofa (pig) | Complex I-23kD,NADH-ubiquinone oxidoreductase 23 kDa subunit |
| 42 | QA (V1) | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 431 | 47235.8 | 1 | UniProt (A0A4X1SZP7) | Sus scrofa (pig) | |
| 43 | RA (V2) | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | polymer | 217 | 23826.3 | 1 | UniProt (A0A287BG40) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase 24 kDa subunit |
| 44 | SA (V3) | NADH:ubiquinone oxidoreductase subunit V3 | polymer | 42 | 5046.5 | 1 | UniProt (A0A287BEK4) | Sus scrofa (pig) | |
| 45 | CB, DB, HB, IB, NB... (AK, AL, B4, B5, N1...) | CARDIOLIPIN | non-polymer | 1464.0 | 12 | Chemie (CDL) | |||
| 46 | WA (A9) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 47 | AC, HC, PC, QB, RB... (N5, S2, S8, N1, N3...) | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine | non-polymer | 744.0 | 9 | Chemie (PEE) | |||
| 48 | OB, YA (N1, A9) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 2 | Chemie (PC1) | |||
| 49 | AB, ZA (AC, AB) | S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate | non-polymer | 568.7 | 2 | Chemie (ZMP) | |||
| 50 | BB (AK) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 51 | CC, EB, FB, GB, LB... (N6, AL, AM, B1, CB...) | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL | non-polymer | 767.1 | 7 | Chemie (PLX) | |||
| 52 | BC, JB, KB, MB, MC (N5, B8, CA, CB, S7) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 5 | Chemie (3PE) | |||
| 53 | PB (N1) | UBIQUINONE-10 | non-polymer | 863.3 | 1 | Chemie (U10) | |||
| 54 | DC, EC, KC, NC, OC... (S1, S7, S8, V1) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 55 | FC, SC (S1, V2) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 56 | GC (S1) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 57 | IC (S2) | Metformin | non-polymer | 129.2 | 1 | Chemie (MF8) | |||
| 58 | JC (S6) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 59 | RC (V1) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 45 |
| Total formula weight | 948117.8 | |
| Non-Polymers* | Number of molecules | 52 |
| Total formula weight | 41265.4 | |
| All* | Total formula weight | 989383.2 |
