9J3Z

Cryo-EM structure of lysosome cholesterol sencing protein in L state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Lysosomal cholesterol signaling protein,G protein-coupled receptor 155 fusion protein	polymer	870	96994.7	2	UniProt (Q7Z3F1) UniProt (G1R1S1) Pfam (PF03547) Pfam (PF00610)	Nomascus leucogenys	LYCHOS,G-protein coupled receptor PGR22
2	C, D, F, G (A, B)	(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate	non-polymer		760.1	4	Chemie (POV)
3	E, H (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

A, B: 1 - 547 (UniProt: Q7Z3F1)
A, B: 548 - 717 (UniProt: Q7Z3F1)
A, B: 718 - 870 (UniProt: G1R1S1)

PDB	External Database	Details
Asp 734	Glu 665	conflict
Thr 735	Ile 666	conflict
Ser 788	Asn 719	conflict
His 866	Arg 797	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	193989.4
Non-Polymers*	Number of molecules	6
	Total formula weight	3482.7
All*	Total formula weight	197472.1

*Water molecules are not included.