9J3X

Cryo-EM structure of lysosome cholesterol sencing protein LYCHOS in Tight-state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Chimera of Lysosomal cholesterol signaling protein and G protein-coupled receptor 155	polymer	870	97039.8	2	UniProt (Q7Z3F1) UniProt (G1R1S1) Pfam (PF03547) Pfam (PF00610)	Homo sapiens (human)	LYCHOS,G-protein coupled receptor PGR22
2	C, H (A, B)	CHOLESTEROL	non-polymer		386.7	2	Chemie (CLR)
3	D, E, F, I, J... (A, B)	(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate	non-polymer		760.1	6	Chemie (POV)
4	G, L (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

A, B: 1 - 591 (UniProt: Q7Z3F1)
A, B: 592 - 870 (UniProt: G1R1S1)

PDB	External Database	Details
Leu 653	Gln 584	conflict
Thr 735	Ile 666	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	194079.7
Non-Polymers*	Number of molecules	10
	Total formula weight	5776.2
All*	Total formula weight	199855.8

*Water molecules are not included.