9J03

Cyro-EM Structure of Human TLR4/MD-2/DLAM1 Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (C, D)	Lymphocyte antigen 96	polymer	142	16385.9	2	UniProt (B3Y6A6) Pfam (PF02221) UniProt (by SIFTS) (Q9Y6Y9)	Homo sapiens (human)
2	C, D (B, A)	Toll-like receptor 4	polymer	605	68838.3	2	UniProt (O00206) Pfam (PF13855) Pfam (PF12799)	Homo sapiens (human)
3	E, F (E, F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	G, H (G, I)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
5	I, J (P, H)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		627.6	2	In PDB GlyTouCan (G47362BJ)
6	K, L, M, P, Q... (C, D, A)	(3R)-3-(dodecanoyloxy)tetradecanoic acid	non-polymer		426.7	6	Chemie (2IL)
7	N, O, T, U, Y... (C, D, B, A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
8	R, V (B, A)	2-amino-2-deoxy-4-O-phosphono-alpha-D-glucopyranose	non-polymer		259.2	2	Chemie (GP4)
9	S, W (B, A)	[(2~{R},3~{S},4~{S},5~{S})-5-methoxy-3,4,6-tris(oxidanyl)oxan-2-yl]methyl dihydrogen phosphate	non-polymer		274.2	2	Chemie (X6Z)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	170448.5
Branched	Number of molecules	6
	Total formula weight	3277.1
Non-Polymers*	Number of molecules	16
	Total formula weight	4953.9
All*	Total formula weight	178679.5

*Water molecules are not included.