9IY7
Cryo-EM structure of the wild-type human serotonin transporter complexed with S-ketamine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium-dependent serotonin transporter | polymer | 636 | 71101.2 | 1 | UniProt (P31645) Pfam (PF03491) Pfam (PF00209) | Homo sapiens (human) | human serotonin transporter (slc6a4),SERT,5HT transporter,5HTT,Solute carrier family 6 member 4 |
| 2 | B (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 3 | C, D (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 4 | E, F, W (A) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 3 | Chemie (Y01) | |||
| 5 | G (A) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 1 | Chemie (LMT) | |||
| 6 | H (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 7 | I (A) | (2~{S})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one | non-polymer | 237.7 | 1 | Chemie (JC9) | |||
| 8 | J, K, M, X, Z (A) | nonane | non-polymer | 128.3 | 5 | Chemie (DD9) | |||
| 9 | AA, L, N, T, V... (A) | DODECANE | non-polymer | 170.3 | 6 | Chemie (D12) | |||
| 10 | O, U (A) | DECANE | non-polymer | 142.3 | 2 | Chemie (D10) | |||
| 11 | BA, P, Q, R, S (A) | N-OCTANE | non-polymer | 114.2 | 5 | Chemie (OCT) |
Sequence modifications
A: 1 - 630 (UniProt: P31645)
| PDB | External Database | Details |
|---|---|---|
| Leu 631 | - | expression tag |
| Glu 632 | - | expression tag |
| Val 633 | - | expression tag |
| Leu 634 | - | expression tag |
| Phe 635 | - | expression tag |
| Gln 636 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 71101.2 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 5030.2 | |
| All* | Total formula weight | 76131.3 |
