9IXY

Human KCNQ2-CaM-Ebio2 Complex in the Presence of PIP2

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Isoform 3 of Potassium voltage-gated channel subfamily KQT member 2	polymer	628	70880.7	4	UniProt (O43526) Pfam (PF00520) Pfam (PF07885) Pfam (PF03520) Pfam (PF16642)	Homo sapiens	KQT-like 2,Neuroblastoma-specific potassium channel subunit alpha KvLQT2,Voltage-gated potassium channel subunit Kv7.2
2	E, F, G, H (E, F, G, H)	Calmodulin-3	polymer	177	19615.4	4	UniProt (P0DP25) Pfam (PF13499)	Homo sapiens (human)
3	I, K, M, O (A, B, C, D)	~{N}-[7-[bis(fluoranyl)methoxy]-1-prop-2-ynyl-indazol-3-yl]-3,3-dimethyl-butanamide	non-polymer		335.3	4	Chemie (A1L3C)
4	J, L, N, P (A, B, C, D)	[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate	non-polymer		746.6	4	Chemie (PIO)

Sequence modifications

A, B, C, D: 64 - 702 (UniProt: O43526)

PDB	External Database	Details
Met 63	-	initiating methionine
Leu 703	-	expression tag
Glu 704	-	expression tag
Gly 705	-	expression tag
Gly 706	-	expression tag
Ser 707	-	expression tag
Ser 708	-	expression tag
Gly 709	-	expression tag
Gly 710	-	expression tag
Trp 711	-	expression tag
Ser 712	-	expression tag
His 713	-	expression tag
Pro 714	-	expression tag
Gln 715	-	expression tag
Phe 716	-	expression tag
Glu 717	-	expression tag
Lys 718	-	expression tag

E, F, G, H: 1 - 149 (UniProt: P0DP25)

PDB	External Database	Details
Leu 150	-	expression tag
Glu 151	-	expression tag
Gly 152	-	expression tag
Gly 153	-	expression tag
Ser 154	-	expression tag
Ser 155	-	expression tag
Gly 156	-	expression tag
Gly 157	-	expression tag
Leu 158	-	expression tag
Val 159	-	expression tag
Pro 160	-	expression tag
Arg 161	-	expression tag
Gly 162	-	expression tag
Ser 163	-	expression tag
Gly 164	-	expression tag
Gly 165	-	expression tag
Ser 166	-	expression tag
Ser 167	-	expression tag
Gly 168	-	expression tag
Gly 169	-	expression tag
His 170	-	expression tag
His 171	-	expression tag
His 172	-	expression tag
His 173	-	expression tag
His 174	-	expression tag
His 175	-	expression tag
His 176	-	expression tag
His 177	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	361984.7
Non-Polymers*	Number of molecules	8
	Total formula weight	4327.7
All*	Total formula weight	366312.4

*Water molecules are not included.