9IXX

Structural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	G-alpha q	polymer	361	41724.4	1		Homo sapiens (human)
2	B (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	351	38744.4	1	UniProt (P62873) Pfam (PF25391)	Homo sapiens (human)
3	C (E)	scFv16	polymer	248	26408.5	1		Rattus norvegicus
4	D (G)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631)	Homo sapiens (human)	G gamma-I
5	E (R)	Cysteinyl leukotriene receptor 2	polymer	337	38506.8	1	UniProt (Q9NS75) Pfam (PF00001)	Homo sapiens (human)	CLTR2,CysLTR2,G-protein coupled receptor GPCR21,hGPCR21,G-protein coupled receptor HG57,HPN321
6	F (R)	(5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-azanyl-3-(2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid	non-polymer		496.7	1	Chemie (LTD)

Sequence modifications

B: 7 - 345 (UniProt: P62873)

PDB	External Database	Details
Met -5	-	initiating methionine
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
Gly 2	-	expression tag
Ser 3	-	expression tag
Leu 4	-	expression tag
Leu 5	-	expression tag
Gln 6	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	153245.2
Non-Polymers*	Number of molecules	1
	Total formula weight	496.7
All*	Total formula weight	153741.8

*Water molecules are not included.