9IXJ
histamine-bound H2R in complex with Gs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 398 | 46067.9 | 1 | UniProt (P63092) | Homo sapiens (human) | Guanine nucleotide-binding protein G(s) subunit alpha (4A),Adenylate cyclase-stimulating G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 347 | 38059.6 | 1 | UniProt (P62873) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) | Homo sapiens (human) | G gamma-I |
| 4 | D (N) | Nb35 | polymer | 161 | 17381.6 | 1 | Lama glama | ||
| 5 | E (R) | Histamine H2 receptor | polymer | 359 | 40138.0 | 1 | UniProt (P25021) | Homo sapiens (human) | H2R,HH2R,Gastric receptor I |
| 6 | F (R) | HISTAMINE | non-polymer | 111.1 | 1 | Chemie (HSM) | |||
| 7 | G (R) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) |
Sequence modifications
A: 1 - 398 (UniProt: P63092)
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Asp 188 | Ala 188 | variant |
| Ala 374 | - | insertion |
| Ala 375 | - | insertion |
| Ala 376 | - | insertion |
| Ala 377 | - | insertion |
| Ile 379 | Val 375 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
| Gly 341 | - | expression tag |
| Ser 342 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 149508.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 497.8 | |
| All* | Total formula weight | 150006.0 |
