9IWZ

Crystal structure of the mouse RIP3 kinase domain in complexed with GSK'843

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Receptor-interacting serine/threonine-protein kinase 3	polymer	325	36213.3	2	UniProt (Q9QZL0) Pfam (PF00069)	Mus musculus (house mouse)	RIP-like protein kinase 3,Receptor-interacting protein 3,RIP-3,mRIP3
2	C, D (A, B)	3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine	non-polymer		377.5	2	Chemie (ZOV)
3	E, F (A, B)	water	water		18.0	277	Chemie (HOH)

Sequence modifications

A, B: 1 - 313 (UniProt: Q9QZL0)

PDB	External Database	Details
Ala 111	Cys 111	conflict
Asp 136	Asn 136	conflict
Lys 198	Asp 198	conflict
Leu 314	-	expression tag
Glu 315	-	expression tag
His 316	-	expression tag
His 317	-	expression tag
His 318	-	expression tag
His 319	-	expression tag
His 320	-	expression tag
His 321	-	expression tag
His 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72426.7
Non-Polymers*	Number of molecules	2
	Total formula weight	755.0
All*	Total formula weight	73181.6

*Water molecules are not included.