9IWT

Crystal structure of human NAMPT complexed with AMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Nicotinamide phosphoribosyltransferase	polymer	497	56423.8	4	UniProt (P43490) Pfam (PF18127) Pfam (PF04095)	Homo sapiens (human)	NAmPRTase,Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin
2	E, I, L, P (A, B, C, D)	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	4	Chemie (AMP)
3	F, G, J, K, M... (A, B, C, D)	PHOSPHATE ION	non-polymer		95.0	8	Chemie (PO4)
4	H, O, S (A, C, D)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
5	T, U, V, W (A, B, C, D)	water	water		18.0	1148	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 491 (UniProt: P43490)

PDB	External Database	Details
His 492	-	expression tag
His 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	225695.2
Non-Polymers*	Number of molecules	15
	Total formula weight	2221.6
All*	Total formula weight	227916.8

*Water molecules are not included.