9IVM
Cryo-EM structure of the GLP-1(9-36)-bound human GLP-1R-Gs complex in the presence of LSN3318839
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 361 | 41879.5 | 1 | UniProt (P63096) UniProt (P63092) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein,Adenylate cyclase-stimulating G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37915.5 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 70 | 7729.9 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (N) | Nanobody-35 | polymer | 140 | 15343.0 | 1 | Homo sapiens | ||
| 5 | E (P) | GLP-1(9-36) | polymer | 28 | 3093.4 | 1 | Homo sapiens | ||
| 6 | F (R) | Glucagon-like peptide 1 receptor | polymer | 440 | 50860.8 | 1 | UniProt (P43220) Pfam (PF02793) Pfam (PF00002) | Homo sapiens (human) | GLP-1 receptor,GLP-1-R,GLP-1R |
| 7 | G (R) | (2~{R})-2-[2-[1-[(1~{R})-1-[2,6-bis(chloranyl)-3-cyclopropyl-phenyl]ethyl]imidazo[4,5-c]pyridin-6-yl]phenyl]propanoic acid | non-polymer | 480.4 | 1 | Chemie (A1EEC) |
Sequence modifications
A: 8 - 26 (UniProt: P63096)
A: 27 - 83 (UniProt: P63092)
A: 84 - 204 (UniProt: P63096)
A: 205 - 253 (UniProt: P63092)
A: 264 - 394 (UniProt: P63092)
B: 2 - 340 (UniProt: P62873)
A: 27 - 83 (UniProt: P63092)
| PDB | External Database | Details |
|---|---|---|
| Asp 49 | Gly 49 | conflict |
| Asn 50 | Glu 50 | conflict |
| Tyr 63 | Leu 63 | conflict |
A: 205 - 253 (UniProt: P63092)
| PDB | External Database | Details |
|---|---|---|
| Ala 226 | Gly 226 | conflict |
| Asp 249 | Ala 249 | conflict |
| Asp 252 | Ser 252 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asp 272 | Leu 272 | conflict |
| Ser 366 | Ala 366 | conflict |
| Ala 372 | Ile 372 | conflict |
| Ile 375 | Val 375 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 156822.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 480.4 | |
| All* | Total formula weight | 157302.5 |
