Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone acetyltransferase p300 | polymer | 349 | 40392.2 | 2 | UniProt (Q09472) Pfam (PF08214) | Homo sapiens (human) | p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein 2-hydroxyisobutyryltransferase p300,Protein lactyltransferas p300,Protein propionyltransferase p300 |
| 2 | C, G (A, B) | 4-[(2~{S})-1-[[(~{R})-[(3~{S})-7-(1-methylpyrazol-4-yl)-2,3-dihydro-1~{H}-pyrido[2,3-b][1,4]oxazin-3-yl]-phenyl-methyl]amino]propan-2-yl]benzenecarbonitrile | non-polymer | 464.6 | 2 | Chemie (A1L3B) | |||
| 3 | D, H (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | E, J (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | F, I (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 6 | K, L (A, B) | water | water | 18.0 | 478 | Chemie (HOH) |
Sequence modifications
A, B: 1287 - 1666 (UniProt: Q09472)
| PDB | External Database | Details |
|---|---|---|
| Met 1286 | - | initiating methionine |
| - | Glu 1523 | deletion |
| - | Glu 1524 | deletion |
| - | Glu 1525 | deletion |
| - | Glu 1526 | deletion |
| - | Arg 1527 | deletion |
| - | Lys 1528 | deletion |
| - | Arg 1529 | deletion |
| - | Glu 1530 | deletion |
| - | Glu 1531 | deletion |
| - | Asn 1532 | deletion |
| - | Thr 1533 | deletion |
| - | Ser 1534 | deletion |
| - | Asn 1535 | deletion |
| - | Glu 1536 | deletion |
| - | Ser 1537 | deletion |
| - | Thr 1538 | deletion |
| - | Asp 1539 | deletion |
| - | Val 1540 | deletion |
| - | Thr 1541 | deletion |
| - | Lys 1542 | deletion |
| - | Gly 1543 | deletion |
| - | Asp 1544 | deletion |
| - | Ser 1545 | deletion |
| - | Lys 1546 | deletion |
| - | Asn 1547 | deletion |
| - | Ala 1548 | deletion |
| - | Lys 1549 | deletion |
| - | Lys 1550 | deletion |
| - | Lys 1551 | deletion |
| - | Asn 1552 | deletion |
| - | Asn 1553 | deletion |
| - | Lys 1554 | deletion |
| Arg 1637 | Lys 1637 | engineered mutation |
| Gly 1652 | Met 1652 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80784.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1308.4 | |
| All* | Total formula weight | 82092.7 |
