9ISE
Human MTHFD1 in complex with LY374571
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed | polymer | 308 | 33590.5 | 4 | UniProt (P11586) Pfam (PF00763) Pfam (PF02882) | Homo sapiens (human) | |
| 2 | E, G, I, K (A, B, C, D) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
| 3 | F, H, J, L (A, B, C, D) | (2S)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1H-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid | non-polymer | 433.4 | 4 | Chemie (9L9) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 502 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 301 (UniProt: P11586)
| PDB | External Database | Details |
|---|---|---|
| Arg 134 | Lys 134 | variant |
| Leu 302 | - | expression tag |
| Glu 303 | - | expression tag |
| His 304 | - | expression tag |
| His 305 | - | expression tag |
| His 306 | - | expression tag |
| His 307 | - | expression tag |
| His 308 | - | expression tag |
| His 309 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 134362.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 4707.1 | |
| All* | Total formula weight | 139069.1 |
