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9ISC

Human MTHFD2 in complex with compound 16a

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrialpolymer31934597.02UniProt (P13995)
Pfam (PF00763)
Pfam (PF02882)
Homo sapiens (human)
2C, G
(A, B)
NICOTINAMIDE-ADENINE-DINUCLEOTIDEnon-polymer663.42Chemie (NAD)
3D, H
(A, B)
(2~{S})-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1~{H}-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]-4-(1~{H}-1,2,3,4-tetrazol-5-yl)butanoic acidnon-polymer457.42Chemie (A1L22)
4E, F
(A)
PHOSPHATE IONnon-polymer95.02Chemie (PO4)
5I, J
(A, B)
waterwater18.080Chemie (HOH)
Sequence modifications
A, B: 36 - 350 (UniProt: P13995)
PDBExternal DatabaseDetails
Gly 32-expression tag
Ser 33-expression tag
His 34-expression tag
Met 35-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight69194.0
Non-Polymers*Number of molecules6
Total formula weight2431.6
All*Total formula weight71625.6
*Water molecules are not included.

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PDB entries from 2025-06-18

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